Judy Foreman

Nationally Sindicated Fitness, Health, and Medicine Columnist

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The Long Road Back

May 12, 1997 by Judy Foreman

Burns, emotional scars linger long after the body has healed.

It was late, almost midnight, a few nights before Thanksgiving. Heather Whiles, then 20, home for the holiday from Columbia University, was cruising down Route 125 on her way from North Andover to Boston to see a friend.

She was sober, but tired, and fell asleep at the wheel.

The rest is a blur. She hit an embankment, uprooted a tree, then passed out when her car burst into flames. Two young men joyriding in a truck stopped to help, as car windows popped and gas sprayed everywhere. “They woke me up by screaming,” she says. “I crawled out a window.”

Burned over 70 percent of her body, she remembers nothing of the helicopter flight to Brigham and Women’s Hospital. Or of the pain and terror that doctors could control only by keeping her heavily sedated in a semi-sleep state for two months. Or of the surgeries every few days to strip away burned skin and cover her wounds with grafts and artificial skin. Or of the six weeks she stayed at Braintree Hospital to work with its burn rehabilitation team.

Today, she looks good – pretty, in fact. She wears a wig to hide the burns on her scalp and a full-body custom-made pressure garment – under her clothes – to keep scarring and itching to a minimum as she heals. She still faces two more years of reconstructive surgery.

Yet she feels her trauma “has made me amazingly strong.” In fact, she wants to go to medical school and become a burn surgeon.

“There’s a million tragedies in the world,” she says with conviction, “and only two ways to handle them: ‘Oh, woe is me, how can I have such bad luck!’ Or to be empowered.”

Empowering people like Whiles who in years past might have died from their injuries is now the cutting edge in burn care.

A half-century ago, in the Coconut Grove fire that killed 492 people, only one man survived with burns over 20 percent of his body, notes Dr. Colleen Ryan, a burn surgeon at Massachusetts General Hospital and the Shriners Burns Institute.

By the 1970s, doctors were saving half of patients with 30 percent burns, according to national figures. Today, half of all people burned over 70 percent of the body survive. And in burn centers, the survival rate, regardless of the depth or percent of body surface area burned, is as high as 94 percent.

The other good news is that fewer people – 1.25 million a year, down from 2 million annually two decades ago – are getting burned these days, thanks to smoke detectors, nonflammable clothing and better occupational safety standards, says Peter A. Brigham, president of the Burn Foundation in Philadelphia.

But along with the remarkable medical progress – much of it attributable to more aggressive surgery to remove burned skin, better skin grafting and earlier use of ventilators to protect damaged lungs – has come a huge, unexpected challenge: How to heal devastated psyches that are often as seared as the skin.

“People who would have died 10 years ago are now being saved,” says Marion Doctor, a clinical social worker at Children’s Hospital in Denver. This means burn teams now have the moral responsibility “not just to save their lives but to offer assistance in getting on with their lives.”

In the past, says Dr. Bob Demling, director of the Brigham and Women’s burn center, “our ability to save lives has exceeded our ability to return to society these individuals as functional, confident human beings.”

But increasingly, mental health specialists are finding ways to help people put their souls back together as their bodies heal, a process that, Demling says, has “very predictable phases, including denial, dependence and hostility.”

Some of the steps in this process are specific to people with disfiguring injuries, burn researchers find, but some are applicable to anyone with a major trauma, whether it’s visible to the world or not.

Dr. Patricia N. Watkins, a psychiatric consultant to the Columbia Augusta Medical Center in Georgia, has identified seven stages that burn patients go through, sometimes over and over.

The first is the “Will I live?” question. It hits people as soon as they become conscious of their injuries. While family members may quickly grasp that an injury is survivable, it often takes longer for the badly burned patient to believe that’s possible.

The next hurdle is believing pain will be controlled. Burn treatment often involves daily cleaning of raw wounds to prevent infection, a process that can be so painful that patients can get trapped in a vicious cycle of pain and fear.

“Anxiety drops dramatically” with good pain medication and psychological support, says Demling, at Brigham and Women’s. The key, he adds, is for burn teams to “break through that barrier of insecurity and anxiety and free up the ability of the patient to actively participate in rehabilitation.”

The challenge then becomes to find meaning in the tragedy.

Curiously, guilt, or at least taking responsibility if the accident was in some way caused by the patient, can help, says Watkins. In fact, the people who often have the toughest time making sense of their trauma are those who were simply victims of bad luck, being in the wrong place at the wrong time.

And while many people suffer because they think their injury must be punishment for some wrongdoing, says Watkins, people also get burned for doing something right – like saving the lives of others – and they, too, may have trouble making sense of it all.

Watkins recalls one woman who was burned over 20 percent of her body when she went into a burning building to try to rescue her father, after she had rescued her kids. “She was sitting there crying, saying, ‘What did I do wrong that I got hurt and he died?’ “

Finding an emotionally comprehensible explanation for the burn is crucial, Watkins adds. Without it, a person may develop post traumatic stress disorder, the way combat veterans and rape victims sometimes do. With an explanation that helps them come to terms with their injury, people are freer to participate in and take pride in their own rehabilitation, even simple accomplishments like enduring the pain of taking a shower.

With each step forward, though, comes a more realistic recognition of the losses, even with burns that are not normally visible to others, says David Chedekel, a psychologist at the Shriners Institute. In fact, recent research suggests that burns “that are not visible can cause as much distress as others,” he says.

Dealing with these losses – including the death of other people in the same accident – can often be accomplished by letting people talk and byproviding a safe place “to express the pain, the anger, the fear,” says James Beauregard, a clinical neuropsychologist at Braintree Hospital, which has one of the nation’s leading burn rehabilition programs.

Because severely burned people may go through dozens of surgeries to close wounds and reconstruct damaged tissue, psychological healing is often a two-steps-forward-one-step-back process as the medical interventions continue.

“Just getting through all the surgeries requires an immense amount of fortitute,” says Demling. “You have to want to get better at the price of looking worse temporarily. That is a real challenge, both physically and psychologically.”

The final emotional step is often the question of identity: Can I be the same person as before? This can be a tough one, especially for young people whose scars are impossible to hide.

But a number of things can help. For Heather Whiles, it was the gift of friendship from Jessica Cirrone, a 23-year old Framingham woman who is also recovering from a bad burn. Both women say that talking together, as well as visiting patients at earlier steps in the recovery process, has been very helpful.

Mental health specialists are also finding ways to help people with bad burns ease back into society. With small children, for instance, some burn centers send teams to their schools to prepare classmates for the return of the burned child.

Others gain confidence in camps for burned children, like those started by Marion Doctor in Colorado in the 1980s.

But whether you’re 8 or 80, re-entry is never easy in a society that puts great emphasis on looks. “One day you don’t have burns, the next day, you do, and you are scarred and disfigured,” says Doctor. “You have to adjust to the non-burned world.”

The miracle is that so many people do. Burn surgeon Ryan has watched in awe as former patients “go back to work and life. People have an innate courage in facing this adversity. It does come out in some people. They do remarkably well.”

“Nobody really knows how the mind works with tragedy,” adds Demling, the Brigham surgeon. “But it is clear that psychological trauma must be treated as aggressively as bodily injury, and with the same level of sophistication. You must deal with both.”

Heather Whiles, he says, has been “very motivated. But if we hadn’t paid attention to the psychiatric impact of this burn, she would have had a harder time getting to the positive point where she is. You see Heather and you see the work of a lot of professionals to bring the true Heather out.”

Whiles herself credits the nurses and other burn team members who have helped her, but also says that ultimately, recovery “is completely internal. You have to reach down and pull yourself up by your bootstraps.”

And she is convinced she will. “Some people talk about how cruel people are to you. But I think you only open yourself up to as much cruelty as you accept.

“I have shown people my back, my head, my hands. Human nature is wonderfully compassionate, but you have to give people a chance.”

For many with cancer the problem is fatigue

May 5, 1997 by Judy Foreman

You might think, to hear about Dr. Wendy S. Harpham’s life, that it’s perfectly obvious why she’s always exhausted.

For one thing, she and her husband run a very busy household in Dallas with three kids, ages 8, 10, and 12.For another, she’s written four books on cancer since 1992 – much easier, she says, than the 15-hour days she used to put in as an internist in solo practice. She’s also in constant demand on the national lecture circuit.

But the real reason that Harpham, 42, is always tired is that she suffers from “post cancer fatigue,” the result of a seven-year battle with lymphoma that forced her to give up her medical practice.

Post cancer fatigue, as she defines it, is fatigue that persists after treatment is over, all known causes of the fatigue have resolved and the patient is in remission. Everyone agrees it’s common, though no one knows for sure how many of the eight million Americans who’ve had cancer suffer from it.

In fact, doctors don’t know much about cancer fatigue, period. That goes for the kind that accompanies debilitating treatments like chemotherapy or radiation as well as the kind that lingers on afterward.

But patients like Harpham do. Once, during treatment, her fatigue was so draining that she remembers sitting at the table thinking, “Oh, my gosh. I have to lift a fork.”

Now, 18 months after her last treatment, she is still so tired she is “always calculating how much energy something I want to do will take, because I always run out.”

Recently, however, a group of cancer specialists and patient advocates called the Fatigue Coalition has begun trying to understand why cancer-related fatigue is so common and, equally important, why so many doctors still don’t take it seriously.

According to a recent coalition survey of 419 cancer patients, 200 caregivers and 197 oncologists, fatigue, not pain, was the patients’ most common complaint. Half were more than a year post-treatment.

Fatigue, the survey also showed, is the problem most likely to chip away at quality of life. Nearly 80 percent of patients experienced fatigue at some point, and more than half said they felt it on most days, if not every day. Many said fatigue affected them to the point where they had trouble working, walking any distance, being intimate with a partner, or meeting the needs of family and friends.

Yet perhaps the most striking finding is this: Most people with cancer think fatigue is something they must put up with.

Only 31 percent even mention it to their doctors on every visit. And when they do, doctors barely hear it: Only five percent of oncologists think patients mention it that often.

To many doctors, fatigue “just doesn’t register on the radar screen as an acute or urgent problem, but for the person with cancer, it’s often the dominating problem,” says Dr. Jerome Groopman, chief of experimental medicine at the Beth Israel Deaconess Medical Center and a member of the Fatigue Coalition.

“When a cancer patient tells a doctor he’s tired, the doctor almost shrugs his shoulders. That’s not a satisfactory answer.”

Especially since some – though by no means all – of the reasons for cancer fatigue can be reversed.

For instance, anemia, low levels of oxygen-carrying hemoglobin in the blood, can often be treated with transfusions or a drug called erythropoietin. Thyroid deficiency, which can occur if radiation to the chest or neck damages the thyroid gland, can also be remedied with medication.

So can the aftereffects of steroid drugs. When people take steroids for long periods and then stop, they often get tired if their adrenal glands can no longer produce enough cortisol. Medication to replace the missing cortisol can help.

Good diet – see a nutritionist if you think you’re not eating right – can also help, as can getting enough rest, even scheduling naps during a busy day.

If Harpham skips her daily nap, “my kids can tell in a minute,” she says. “I make mistakes and I’m not as nice or patient. I’ll forget to do something they asked me to do. I cry more easily. We have all learned that Mom’s getting a nap is an important part of the day.”

Anxiety and depression, which can also lead to fatigue, are also highly treatable with counselling or medication.

Paradoxically, exercise also seems to help people who may feel almost too tired to move, probably by fighting the loss of conditioning that comes from too much lying around.

There is a caveat here, warns Harpham: You have to keep “listening to your body,” because the same amount of exercise that can boost energy one day may sap it the next. But overall, moderate exercise is probably a boon.

Last week, German researchers reported in the journal Cancer that exercise, not rest, was more likely to restore vigor in patients who had undergone high-dose chemotherapy and stem cell transplantation, which is similar to bone marrow transplant.

Although the study involved only 32 patients and had some methodological weaknesses, the results are striking and important, says Dr. Harmon Eyre, executive vice president for research and cancer control at the American Cancer Society.

“Twenty-five years ago, we had people recuperating from surgery lie around in bed. Now we have learned that if we get them up . ., you get them out of the hospital” sooner. The German study suggests exercise may be similarly beneficial to people with cancer.

Don’t panic, we’re not talking marathons here. In the German study, the exercisers started off gingerly – three minutes on the treadmill, five times a day, then worked up to 30 minutes per session after six weeks. By then, though, they were in far better shape than the non-exercisers – they lasted longer on treadmill tests and their hemoglobin counts were higher.

Still, there is much that researchers do not understand.

Fatigue “is clearly related to low white blood cell counts,” says Dr. Nicholas Vogelzang, an oncologist at the University of Chicago and member of the Fatigue Coalition.

But no one really knows why. Perhaps the body’s hormone balance gets out of whack. Perhaps the weakened immune system is using lots of energy trying to fight infections.

Or perhaps substances like TNF, or tumor necrosis factor, released by white blood cells, cause the fatigue.

In addition, people with cancer don’t metabolize the calories they eat efficiently. “It’s very clear that cancer patients don’t handle nutrients in the normal fashion,” says Eyre.

Despite all the unanswered questions, says Harpham, it’s crucial for patients who have fatigue to tell their doctors about it – and for doctors to listen.

And when healthy friends or colleagues say “I’m tired, too,” she suggests telling them, gently, that they really don’t understand at all.

Cancer surivors with fatigue, she says, “never feel rested. And if you look great, you have to keep explaining yourself, because you can’t perform the way someone with normal energy can.”

Where to learn more

If you want to read more about cancer fatigue, you might try the following books by Dr. Wendy S. Harpham:

  • When a Parent Has Cancer: A Guide to Caring for Your Children; and Becky and the Worry Cup (two-volume set); HarperCollins; 1997.

  • After Cancer: A Guide to Your New Life. W.W. Norton, 1994; paperback edition, HarperPerennial; 1995.

  • Diagnosis: Cancer. Your Guide Through the First Few Months; W.W. Norton; 1992.

  • You may also want to read:

  • Taking Control of Fatigue, a free booklet, video and daily journal; available through the American Cancer Society, 1-800-227-2345 begin_of_the_skype_highlighting              1-800-227-2345      end_of_the_skype_highlighting.

  • Everyone’s Guide to Cancer Therapy; by Malin Dollinger, M.D., Ernest H. Rosenbaum, M.D. and Greg Cable; Somerville House Books.

Herb found to aid mild depression

April 28, 1997 by Judy Foreman

Karin Taylor, 58, a tax accountant in Toronto, was stumped. She had a good  marriage, two “wonderful kids,” and a job she loved. 

“I had no reason whatsoever to feel depressed,” she says. “Yet there it  was.”

Sure, she was aware in the back of her mind of her family history of  depression, including three relatives who committed suicide. But she had always felt fine, until a year ago, when, for no obvious reason, life just  lost its zest.

She tried every self-help trick in the book – meditation, positive  thinking, creative visualization. Nothing worked.

Desperate, she finally saw a doctor and, putting aside her fear of side  effects, agreed to a prescription for Paxil, an antidepressant drug. But  she never took it.

Just as she was about to, a longtime woman friend came to visit, bringing along an herbal antidepressant called St. John’s wort, or Hypericum perforatum, which is sold as a dietary supplement.

Taylor tried it – three 300 milligram tablets a day – and now says she  feels “wonderful. I just feel completely natural – no highs, no lows. I  just feel the way I always recall feeling.”

Taylor’s woman friend swears by it, too, saying the herb “took away the underlying total  gray cloud” that had always been with her, despite 10 years of therapy,  12-step programs, exercise and a prescription antidepressant, Effexor,  which she still takes.

St. John’s Wort, or Johanniskraut, has become the antidepressant of choice  in Germany, where it outsells Prozac 7-to-1; in fact, it outsells all  other antidepressants combined.

It’s taking off here, too, says industry analyst Patricia Negron of Adams, Harkness & Hill in Boston. Sales began to grow last fall, she says, and  have “been building ever since.”

The herb “is probably going to be one of the biggest herbs of 1997,” says  Mark Blumenthal, executive director of the American Botanical Council, a Texas research and educational group. “It’s driven not by market hype but by clinical data.”

Many people with depression, of course, are successfully treated with “talk therapy,” prescription antidepressants or both. But as alternative medicine grows in popularity, it is perhaps no surprise that people are turning to herbal remedies for psychiatric as well as physical ills.

Often, mainstream American doctors scorn or ignore herbal remedies because they can’t find studies on the products’ safety or efficacy in medical  journals. With St. John’s wort, they can.

Last August, the British Medical Journal published a compilation of 23  randomized trials of the herb involving 1,757 patients with mild or  moderate depression. In 15 of the trials, some people were given the medication and others a dummy drug; in eight, people were given either the  herb or standard antidepressants.

Some of the studies were flawed – definitions of depression were not  always consistent with American definitions, for instance – but the  results were encouraging. They showed that the herb was “significantly superior to placebo” and “similarly effective as standard  antidepressants.”

Furthermore, side effects like upset stomach occurred in less than 20 percent of people taking the herbal remedy, compared to more than half of  those on standard antidepressants.

The October, 1994 issue of Geriatric Psychiatry and Neurology was devoted to data on the herbal antidepressant as well.

Promising as all this seems, there is a major problem: Nobody really understands quite how it works.

One theory that it acts like a type of prescription antidepressant called a monoamine oxidase inhibitor, or MAOI, has been discredited, easing  concerns that St. John’s wort users would have to avoid foods that react  badly with MAOIs.

But these findings leave wide open the question of how the herb does work.

For years, researchers assumed that the key ingredients are hypericin and  pseudohypericin, but these chemicals do not seem to cross the blood-brain barrier, a membrane that protects the brain. That raises the question of  how they can affect brain chemistry.

One possibility is that the chemicals may act on immune cells that then secrete chemicals that do cross the blood-brain barrier.

Others think the herb may increase brain levels of the neurotransmitter serotonin, as many prescription antidepressants do. If so, the key  ingredient may be turn out to be a third constituent, hyperforin.

Other theories are that the herb lowers levels of the stress hormone cortisol or that it acts on receptors called GABA on brain cells.

However it works, St. John’s wort is cheap – about $ 10 for a month’s supply in health food stores, compared to about $80 for a two-to-four-week supply of Prozac.

It also seems to have little toxicity, unlike some prescription antidepressants that can cause agitation, inhibition of sex drive, dry mouth, urinary retention and, in rare cases, abnormal bleeding.

The herb seems to help “with no side effects, really, for mild  depression,” says Dr. Michael Jenike, associate chief of psychiatry at  Massachusetts General Hospital. “I’m sure Prozac would come out ahead for any kind of moderate to severe depression. But for mild depression, St. John’s wort may be just as good.”

Dr. Harold H. Bloomfield, a psychiatrist in Del Mar, Calif., agrees, noting that the herb “is used by well over 20 million people” in Europe.

Because it is not clear how well, if at all, St. John’s wort works in more severe depression, most researchers warn that you should not even consider  it – or any do-it-yourself approach – if you are seriously depressed or  suicidal.

Instead, get to a psychiatrist or other licensed mental health professional who can assess your situation and offer treatment that’s already well-tested in this country.

And never take St. John’s wort along with any other psychoactive medication, warns Varro Tyler, a plant medicine specialist emeritus from Purdue University.

Jenike agrees. “Absolutely, you should not mix” this with other medications, “and I would be very careful with alcohol, too.” Mixing antidepressants, even mainstream prescription forms, can be fatal.

St. John’s wort has also been associated with sun sensitivity in animals,  which means users might be more sensitive to sunburn.

Despite such caveats, if you’re one of the millions of Americans like Taylor’s woman friend who have been slogging through life in a gray cloud, the herbal  antidepressant might help.

In fact, the National Institute of Mental Health and the Office of  Alternative Medicine are are excited enough about it that they are  planning to seek proposals from psychiatrists willing to study it.

“Everyone wants to apply,” says Jerry Cott, chief of the pharmacological  treatment research program at NIMH.

Taylor’s woman friend is already a convert. She used to think antidepressants of any  kind were “unnatural.” Now, she says, “it was the gray cloud I lived under  that was unnatural.”

Don’t wait for allergy to hit; strike first

April 21, 1997 by Judy Foreman

There may still be patches of snow smothering your crocuses, but believe it or not, springtime allergy season is only about 10 days away – and for some poor souls it’s already begun.

But you may be able to head off trouble before it starts.At least that’s the current thinking of allergy specialists, who say that if you’re among the 26 million Americans likely to get allergic rhinitis, or hay fever, consider calling your doctor now to start taking medications before symptoms get bad.

There’s also another reason to attack allergies before they attack you. The medications are getting better – and we’ll get to the newest ones in a minute.

Allergies, miserable as they can be, simply mean that “the body is making an inappropriate immune response” to specific triggers, or allergens, in the environment, says Dr. Marshall Plaut, chief of the allergic mechanisms section at the National Institute of Allergy and Infectious Diseases.

Altogether, about 50 million of us are allergic to something – either seasonal, outdoor things like trees and grasses, or year-round indoor things like mold, dust or cats. Or both.

In the spring, the big culprit is pollen – a packet of male genetic information that trees and grasses release into the air to be carried to female organs in the same plant or one nearby.

Right now, it’s pollen from elms, willows, poplars, and maples that is likely to cause the most grief. By May, it’ll be the oak, birches, and beeches. By June and July, grass pollen will be the culprit; and by Labor Day, ragweed.

Depending on your genetic makeup, pollen from a particular kind of tree, say a birch, may cause an immune reaction – release of a type of antibody called IgE. This antibody sits on the surface of mast cells – immune cells that line the nose, throat, gastrointestinal tract and skin.

The next time this pollen enters your system, it combines with these antibodies, causing the mast cells to release histamine and other chemicals that trigger an allergic reaction. These chemicals make blood vessels dilate and leak proteins into tissues, causing swelling – the stuffy noses of allergy sufferers – or hives on the skin.

Usually, this is just annoying. But allergies are also the leading cause of asthma, an inflammation of the bronchial tubes. Like colds, allergies can also trigger sinusitis, an inflammation of the sinus cavities around the eyes and nose.

The basic problem is that “allergies can swell your nose internally,” says Dr. Marvin Fried, chief of ear, nose and throat medicine at the Beth Israel Deaconess Medical Center and Brigham and Women’s Hospital.

Once the sinuses become blocked, mucus cannot drain properly, which means that any virus or bacterium can “set up shop in this nice warm environment,” he says. Infected mucus then drips into the lower respiratory tract, where it can cause bronchitis and asthma. It can also seep into the eye or brain, where, in rare cases, it can cause life-threatening infections.

So what can you do?

“Call the doctor now. Get a jump on the allergy season. If you wait until Memorial Day and you’re feeling miserable, you’ll need even more powerful medications,” says Dr. Julian Melamed of Allergy and Asthma Specialists in Chelmsford.

And if you’re discouraged because medications you’ve tried in the past haven’t worked or caused too many side effects, call anyway, because there are new products available this spring.

These include Astelin, a recently-approved antihistamine nasal spray that should not make you sleepy because it acts only in the nose, not throughout the body; Nasalcrom, an anti-inflammatory spray once available by prescription but now available over the counter; and Allegra, an antihistamine pill that does not cause drowsiness or heart rhythm disturbances, as its more famous, soon-to-be-banned cousin, Seldane, does.

The main preventive measure to start now, says Melamed, is an anti-inflammatory nasal spray. One choice is Nasalcrom, a safe drug that does not contain steroids but that is relatively weak and does not work for everybody.

You could also try one of the more powerful prescription corticosteroid sprays, such as Vancenase, Beconase, Flonase or Nasacort . These can be very effective, but can also cause nasal dryness and in large doses over many months can irritate the eyes. In children, they may intefere with growth, but only at high doses.

These medications, which keep down swelling in the nose by damping down the inflammatory response, usually take a number of days to begin working. So if your doctor agrees, you may want to start taking them soon so they will have kicked in by the time the trees and grasses start pollinating.

Antihistamines, which act through a different mechanism to block release of histamine, usually work faster than the anti-inflammatory drugs. Talk to your doctor about what antihistamine to use and when to start using it.

Traditionally, the over-the-counter formulations have worked well but also caused drowsiness. “In recent years, the big advance has been development of nonsedating antihistamines,” says Dr. Paul Chervinsky, president of the New England Research Center in Dartmouth, a private group that tests allergy drugs. But these drugs are available only by prescription.

The initial star in this category was Seldane, but in January, the US Food and Drug Administration announced its intention to withdraw approval of Seldane because it has contributed to cardiac arrhythmias in people who were also taking certain antibiotic or antifungal drugs.

Besides, the FDA reasoned, there is now a better alternative: Allegra, which was approved last summer and, like Seldane, is made by Hoechst Marion Roussel.

Other nonsedating antihistamines that may help are Claritin, the biggest seller, and Zyrtec, which can cause some drowsiness. There’s also Hismanal, which is still on the market but has been linked to the same cardiac problems as Seldane.

But you may have to fight for these drugs. Some cost-conscious managed care plans ask doctors not to precribe nonsedating antihistamines, which can cost roughly $ 60 a month.

In addition to antihistamines, which relieve runny noses, sneezing and watery eyes, decongestants like Sudafed can help with other symptoms, notably a stuffy nose, by constricting blood vessels. The oral decongestants can raise heart rate and blood pressure and contribute to insomnia, so you may want to avoid them at nighttime.

The decongestant sprays like Afrin and Neo-Synephrine cause fewer of these problems, but they can cause stuffiness to “rebound” if used for more than three days.

If all else fails, you may need allergy “shots,” a series of injections that can train your immune system not to overreact every time a speck of pollen comes along. But this treatment can take months to complete, so you probably can’t count on it for this year’s allergy season.

And if your allergies seem to be evolving into asthma or sinusitis, it’s all the more reason to call the doctor.

“In the middle of it, it’s hard to tell” whether you’ve got a cold, allergies or sinusitis, says Fried of Beth Israel. But the American Academy of Otolaryngology now offers some rules of thumb for sorting it out.

With allergies, for instance, the nasal discharge is usually clear, thin and watery. But it turns thick and yellow-green, or you develop a fever, bad breath, pain in your upper teeth and you feel quite sick for 10 to 14 days, you may have a bacterial sinus infection.

The usual treatment for that is a long – three to six weeks – course of antibiotics, though a recent study in the medical journal Lancet questions how effective such treatments are.

If sinusitis becomes a chronic problem, as it does for about 35 million Americans, you may also consider endoscopic surgery – in which doctors insert instruments through the nose to make holes for better drainage of sinus cavities.

The procedure is not without risk, says Fried, a pioneer in the method, because probing the sinuses brings surgical instruments close to the eyes and brain. But the safety of this procedure, now done 250,000 times a year, has improved considerably with imaging techniques that allow a surgeon to “see” exactly where the instruments are.

And if your allergies bring on significant coughing or trouble breathing, you may have asthma.

“Asthma is a major sequel of allergies,” says Melamed of Chelmsford. In fact, allergies are the most common cause of asthma, which, though treatable, kills 5,000 people a year.

The cornerstone of asthma treatment is still inhaled steroids to dampen down the inflammatory response, but two newly approved drugs – Accolate and Zyflo – may also help by blocking the chemical chain reaction that sets off the asthma response.

“If you have asthma, it’s even more important that you treat allergies,” says Plaut of the allergy institute. There is even some evidence that children who get allergy shots may be less likely to develop asthma later, though this is unproved.

The take-home message, he says, is that “while allergies cause a lot of discomfort and can cause significant illness, there are treatments that can improve your quality of life.”

Telling symptoms

It can be hard to determine if you’ve got a cold, allergies or sinusitis. Colds get better by themselves, but allergies and sinusitis persist and often need medical treatment. Here are the distinguishing symptoms.

Symptom Sinusitis Allergy Cold Facial pressure/pain YES Allergy Sometimes Cold Sometimes

Duration of illness Sinusitis More than 10-14 days Allergy Varies Cold Less than 10 days

Nasal discharge Sinusitis Thick, yellow-green Allergy Clear, thin, watery cold Thick and whitish or thin and watery

Fever Sinusitis Sometimes Allergy NO Cold Sometimes

Headache Sinusitis YES Allergy Sometimes Cold Sometimes

Pain in upper teeth Sinusitis Sometimes Allergy NO Cold NO

Bad breath Sinusitis Sometimes Allergy NO Cold NO

Coughing Sinusitis YES Allergy Sometimes Cold YES

Nasal congestion Sinusitis YES Allergy Sometimes Cold YES

Sneezing Sinusitis NO Allergy Sometimes Cold YES SOURCE: American Academy of Otolaryngology.

How music tunes our mental strings

April 14, 1997 by Judy Foreman

Music fills the days at the John Eliot Elementary School in Needham.

When recess is over a teacher may put something soothing on the classroom CD or tape player, perhaps a Baroque piece whose steady rhythm evokes the 60 beats a minute of a heart at peace.

When kids study the solar system and make splatter paintings of the heavens, they listen to “The Planets” by Gustav Holst.

When they study the Colonial period, they write their own songs about the Boston Tea Party, says principal Miriam Kronish, who is also a musician.

And when they take the state MEAP exams in reading, science, social studies and math, these music-drenched kids soar like the voice of soprano Kiri Te Kanawa. The highest possible score on those tests is 1,600; on the latest tests, no child from the John Eliot scored less than 1,570.

This virtuoso performance fits with other data showing that older kids who’ve studied music – or the arts in general – score higher than average on both the verbal and math parts of the SATs, according to the College Board, sponsor of the tests.

Is there really a connection between the magic of music and the way the brain develops?  There appears to be, says a growing chorus of neuroscientists and psychologists.

Music, of course, should be enjoyed for its own sake, not for whatever it may do for brain cells. But there is compelling evidence that making and listening to music, starting as early as possible, may also build brain power.

In fact, some researchers now speculate that early exposure to music may help preserve some of the millions of brain cells a baby is born with that might be lost if they were not used.

“Music is as much a part of the human condition as language – we are born with the machinery to make and appreciate it,” says Dr. Mark Tramo, a Harvard Medical School neuroscientist. “It’s all there. All we have to do is turn it on.”

By the time a baby is born, the cochlea, part of the inner ear, is already equipped with a rubber-band-like membrane that can vibrate in response to sound waves.

Sound waves, which consist of air molecules vibrating at different frequencies, are created all the time – whenever a car screeches, a steak sizzles or a violinist plays an “A.” The “amazing” thing, says Tramo, is that specific sets of nerve cells respond to specific frequencies. For instance, some nerves respond to the middle A on the piano, which vibrates at 440 Hertz, or 440 cycles per second. Other nerves respond to middle C, about 262 Hertz.

“The miracle is that the physics of the sound vibration and the physiology of the ear and brain match so well. We’re born ready to hear – and love – music,” he says.

Babies as young as four months old appear already capable of understanding musical structure, according to a series of ingenious experiments by psychologist Carol Krumhansl of Cornell University and others.

In a typical experiment, the baby is placed in a dark room. When a light goes on, the baby turns her head toward it. As soon as she does, music comes on and stays on until she turns her head away.

Babies quickly learn, says Krumhansl, that the music plays only when they are looking at the light. Once the infants make the connection, the researchers play minuets by Mozart. Sometimes, they are played just as Mozart wrote them. Other times, they are played with long pauses between notes, a disruption that “sounds terrible” to adults, Krumhansl laughs.

The babies think so, too. When Mozart is played right, babies look at the light for long periods. When the musical structure is broken up, they look away. Stanford researchers have documented the same effect with Bartok and Bach.

“Babies are born with a sense of music,” Krumhansl says, adding that studies suggest that even young babies know a cadence – a set of chord patterns that often signals the end of a piece – when they hear one. And they prefer consonant music, with its pleasant-sounding chords, to dissonance, which often sounds harsh or out of tune.

Furthermore, it is becoming clear that specific types of music training can enhance certain intellectual skills, say Frances H. Rauscher, a psychologist at the University of Wisconsin, and Gordon Shaw, a physicist at the University of California at Irvine.

In their latest study, published in February, Rauscher, Shaw and their team took 78 three- and four-year-olds from working-class families and divided them into four groups. One group had six months of private piano lessons; another got computer lessons, a third, singing lessons and the fourth, no training. Unlike the kids who learned piano, Rauscher notes, those given singing lessons were taught little about musical concepts.

By the end of the study, the piano students scored 34 percent higher than the others on a test of spatial-temporal reasoning – putting a puzzle together to gauge their ability to process information in sequence and space.

 “It’s a very definite, causal thing,” says Shaw. “You use large parts of the brain when you’re doing anything at a high level, like processing music.”

Rausher and Shaw also documented the “Mozart effect” in college students. Several years ago, they found that just listening to the complexities of Mozart’s piano sonatas increased scores on temporal-spatial reasoning tests, while listening to relaxation tapes or music by Philip Glass, which is more hypnotic, did not.

But in the college-age kids, the “Mozart effect” lasted only about 15 minutes, notes Rauscher, while the brain-boosting effect of piano lessons for little kids seems to last at least a week.

There is also growing evidence of a “critical period” – roughly the first seven years of life – during which music training is most likely to help brain development, says Dr. Gottfried Schlaug, a neurologist at Beth Israel Deaconess Medical Center.

In one study of right-handed musicians, Schlaug used modern imaging techniques like MRI to examine the corpus callosum, the structure that links the two halves of the brain. To play an instrument that involves both hands, such as the piano, a person must transfer information quickly from one side of the brain to the other.

Schlaug found that in musicians who started playing before age 7, the corpus callosum is bigger than in those who started after age 7.

In another study of pianists, Schlaug found that the motor cortex – the part of the brain that controls movement, including movement of fingers – was more symmetrical in those who started playing before age 7 than in those who started later.

All the musicians were right-handed, which means that researchers expected the left side of the motor cortex to be well-developed because the right side of the body is controlled by the left half of the brain, and vice versa.

Surprisingly, among musicians the right side of the motor cortex was equally strong, especially among those who started early. Most likely, this is because, as kids, these musicians used the fingers on their left hands so much.

A German study of right-handed musicians who play string instruments – and use the fingers on their left hands to press on the strings – bolsters this idea. In the right motor cortex, the spaces between areas that control the thumb and pinky were wider apart than normal, especially among those who started playing early.

Perfect or absolute pitch – the ability to identify one tone without reference to others – may also be honed early. Chances are, Schlaug says, that “if you don’t get exposed to music before age 7, you don’t have it.”

So what can you do to keep kids’ music neurons humming?

“It’s use it or lose it,” says Tramo. “If you want to maximize your children’s intellect, give them music lessons.”

That philosophy underlies Harvard’s Project Zero program, led by neuropsychologist Howard Gardner, who has long believed that music is one of the basic forms of intelligence.

You can also fight for arts programs in schools and communities. Budget cutters often see the arts as frills, says Jim Simpson, executive director at the South Shore Conservatory, which teaches 2,000 kids a year in Hingham and Duxbury. But the arts “are not an adjunct,” he says. “They are an important intellectual development area.”

The bottom line, says Schlaug, is that “any kind of music, either listening or practicing, is able to shape the structure and function of the brain. So anything you can do to enhance a child’s attraction to music will help.”

 

People, and pets, touting arthritis remedy

April 7, 1997 by Judy Foreman

Dr. Margaret Slater, a veterinarian and epidemiologist at Texas A & M University, gives the stuff to all her loved ones, two-footed and four-footed, who suffer from arthritis.

“My dog, my horse, my mother and her dog are all benefitting from it,” she says with a chuckle.

Dr. David Hungerford, chief of orthopedics at the Good Samaritan Hospital in Baltimore, is waiting to see – and perhaps even conduct – a clinical study on the substance.

But meanwhile, this Johns Hopkins surgeon whose arthritic hands perform 300 joint replacement operations a year, many on people with arthritic knees, has begun taking the stuff himself.

“I’ve had significant improvement,” he says.

In Toronto, Dr. Joseph B. Houpt, director of rheumatology at Mt. Sinai Hospital, is already doing a study, prompted by enthusiastic reports from patients who buy the remedy in health food stores. And by watching his dog.

“I have two yellow Labs,” he says. “One was creaking and groaning, unable to jump over stumps, unable to jump up on the couch.” She’s been “like a pup” since she’s been on the drug.

Oops. We are not supposed to call this stuff a drug, no matter how much it sounds – or acts – like one. Officially, it’s a dietary supplement, actually two supplements called glucosamine and chondroitin sulfate, which are made naturally in the body and are found, in tiny quantities, in food.

The supplements have been selling briskly, thanks to high profile reports in the media and a best-selling book with a vastly over-hyped title.

Taken separately, the supplements appear safe, based on studies in Europe, and to protect against the cartilage destruction that is the hallmark of osteoarthritis, which affects 16 million Americans. Rheumatoid arthritis affects another 2 million.

Because they are sold as supplements, these products are available in health food stores, pharmacies or by mail order. They are not approved by the Food and Drug Administration which means, of course, that you don’t have the government’s assurance that the products really work and are safe.

Still, these alternative remedies are clearly setting America’s arthritic toes a-tappin’ and hands a-clappin’ – as they have in Europe for years in both oral and injectable versions. (The injectable form is not available here.)

At the Bread and Circus store in Cambridge, one combination product, Joint Fuel by Twin Laboratories, is selling “extremely well,” says acting assistant nutrition manager Catherine Devine. And another, marketed as Glucosamine Chondroitin Complex by the Solgar Vitamin and Herb Company, is sold out.

Glucosamine or chondroitin are selling well separately, too.

The only patented combination product is Cosamin, made by Nutramax Laboratories, Inc. in Baltimore, which also makes a nearly identical product, Cosequin, for animals. Like the health food products, Cosamin, which Nutramax may someday try to market as a drug, is a hot seller in pharmacies and doctors’ offices – $ 100 for a 60-day supply for a person under 200 pounds.

So far, there is not a single published study on the combination of glucosamine and chondroitin in humans, although several on Cosamin are in the works, says Dr. Todd Henderson, a veterinarian and vice president of Nutramax. Several studies of the combination product show promising results in animals.

But there are a number of European studies in people that suggest that, taken separately, glucosamine or chondroitin can help substantially. Glucosamine probably works by stimulating the cells that make cartilage, and chondroitin, by inhibiting cartilage breakdown.

Much of the fascination with these supplements has been triggered by the best-selling, if misleadingly-titled book, “The Arthritis Cure,” by Dr. Jason Theodosakis, a Tucson physician. Theodosakis says the osteoarthritis in his knees and one elbow was so bad he was on crutches and “couldn’t even brush my teeth.”

Despite surgery, he was convinced he would never live without pain and stiffness, despite high doses of anti-inflammatory drugs. But within two weeks of taking the dietary supplements, he says, he began experiencing a “dramatic recovery.”

Since then, he says he’s treated hundreds of people, though he sounds slightly chagrined at having used the word “cure” in his title, which the American College of Rheumatology calls “irresponsible” and the Arthritis Foundation, “deceptive.”

In an interview and in the book, Theodosakis is more cautious, saying he needed ” a catchy title” and that he’s talking about curing symptoms, not the disease itself.

Others studying glucosamine and chondroitin are also trying to temper the growing public enthusiasm.

Dr. David Eisenberg, a self-described “open minded skeptic” and director of the center for alternative medicine research at Beth Israel Deaconess Medical Center, is intrigued but cautious, because people with arthritis are so eager to try anything that might help. Eisenberg is considering whether to conduct a study of sea cucumbers, a Chinese remedy for arthritis.

Dr. Amal Das, an orthopedic surgeon in Hendersonville, N.C. who does knee and hip replacement surgery, is already conducting a double-blind, placebo-controlled trial of Cosamin in 100 arthritis patients.

At regular intervals, patients complete a questionnaire assessing their pain, says Das, who has previously studied other medications to help patients avoid joint replacement surgery.

In Toronto, rheumatologist Houpt is also doing a double-blind study on 100 patients, though he is testing glucosamine alone, not the combination product. He’s heard the promising anecdotes, but warns, “You have to have a balanced approach to this. That’s why it’s important to look at large populations.”

Hungerford, the Johns Hopkins surgeon, agrees, adding it is “theoretically possible” that the supplements, if taken before cartilage is destroyed, could reduce the need for some of the 200,000 knee replacements and more than 200,000 hip replacements done every year.

“But in order for me and thousands of other physicians to become convinced that this is the recognized and preferred first line of treatment, double-blind, placebo-controlled, multi-centered trials need to be done,” he says.

And unless these studies are done and the FDA gives its blessing, there’s no way to be sure that what you buy will work and be safe, or even that the labels on the bottles will tell the truth. In fact, one study of nearly 30 glucosamine or chondroitin products found that several did not contain the doses specified.

“I can’t imagine there are real big safety problems,” says Dr. David Felson, a rheumatologist at Boston Medical Center. And the FDA says it has received no complaints about either dietary supplement.

But Felson warns, “You don’t know what else might be in the stuff that you buy in the health food store.”

If you do decide to treat yourself, the dose Theodosakis suggests is 1,500 milligrams of glucosamine and 1,200 milligrams of chondroitin sulfate per day for a person who weighs between 120 and 200 pounds.

Three tablets of Cosamin provides that dosage. Each tablet also contains 66 milligrams of ascorbate and 10 milligrams of manganese to enhance absorption. But other combination products may not meet this suggested dose. Each table of Joint Fuel, for instance, contains only half as much glucosamine and only a tiny bit, 17 milligrams, of chondroitin.

If you want to try the supplements, you should definitely talk it over with your doctor, among other things, to confirm that you really do have arthritis and not some other problem.

But the bottom line, says Das of North Carolina, is that it’s “probably okay” to try the supplements, especially since “there are no known side effects.”

The risks, in other words, are all yours. But the benefits may be, too.

Should you take that test?

March 24, 1997 by Judy Foreman

For people with no symptoms routine screening can have a downside.

A little over a week ago, a group of cancer gurus, having pondered 40 studies on the potential value of screening men for prostate cancer, ended up much like a hung jury.

The preponderance of the evidence, they concluded, simply did not show, as many had hoped, that the benefits of testing every man over 50 for prostate cancer outweighed the risks.

There are possible, though unproven, benefits to catching cancer early. But these potential benefits don’t outweigh a more clear and present problem – that worrisome results on screening tests set men up for yet more testing, often followed by surgery and radiation that can lead to impotence and incontinence.

If these risks scare you more than cancer – which might not kill you for years – you may want to skip this test, the doctors suggest.

In January, a panel convened by the National Institutes of Health slogged through 100 studies and came to a similarly dreary conclusion about mammograms for women between 40 and 49.

Mammograms clearly save lives for women over 50. But 98.5 percent of women who get annual mammograms in their 40s get no benefit, says biostatistician Donald Berry of Duke University, a member of the panel. The others do benefit some – gaining on average 200 extra days of life, he says.

Like the men who go through invasive testing after prostate screening, many women with suspicious mammograms find out they’re okay only after more tests and often, surgery.

Now, if you happen to be the one whose life is saved by screening, you’re undoubtedly a true believer. And some medical groups, including the American Cancer Society, agree, reasoning that it’s often better to know what’s going on sooner rather than later. This may be especially true for people at high risk of a disease.

But for people at normal risk, faith in testing is coming under attack as evidence for the downside of screening grows.

“The problem with screening is that it can put you on a slippery slope. And if you know enough about that slippery slope in advance, you may not want to walk out on it,” says Dr. Harold Sox, chairman of the department of medicine at Dartmouth Medical School and president-elect of the American College of Physicians.

“Every screening test will have its downside, not only because of the potential risks of the diagnostic workup plus the therapy, but because it will flag many people as abnormal who don’t have cancer,” adds Dr. Barry Kramer, deputy director of cancer prevention and control at the National Cancer Institute.

The dilemma in screening huge numbers of asymptomatic people boils down to a deceptively simple question – is it worth it?

If the screening test is for a disease for which there is a treatment that clearly works without causing too many side effects, it probably is. If there is no treatment that prolongs life significantly, or if the treatment causes harm, it may not be.

Complicating this are other knotty issues – like whether catching something early really leads to more years of life or just more years of knowing you have the disease – the so-called “lead time bias” question.

Often, the decision to be screened “depends on subjective responses that vary enormously from one person to another,” says Dr. Albert Mulley, chief of general medicine at Massachusetts General Hospital.

Many women in their 40s swear by mammograms for the reassurance value – even though in this age group they miss up to 25 percent of invasive cancers. (Among older women, mammograms miss only about 10 percent.)

On the other hand, many men – half, in Mulley’s experience – respond with a firm “No thanks” when told about the tests and treatments that can follow screening with a digital rectal exam or a blood test for PSA (prostate specific antigen).

But it’s not just personal factors like family history or fears of a particular disease that make these decisions so hard.

It’s that, with depressing regularity, different panels of experts look at the same data and come to opposite conclusions.

Sometimes, of course, the data do finally line up one way or the other. Though cholesterol screening has been controversial, many people are tested regularly, believing that if their cholesterol is too high and they lower it, they can reduce their heart attack risk.

The data that clinched the case, the so-called West of Scotland study, came only about a year ago, says Dr. Daniel Levy, director of the Framingham Heart Study. The study showed that, at least among middle- aged men, lowering cholesterol with medication reduces the risk of a first heart attack. In this case, screening clearly pays off.

But many screening decisions aren’t so simple when you look at the evidence on treatments, the quality of the studies, and how much doctors’ groups vary in the criteria they say a test must meet to be worthwhile.

For instance:

Prostate cancer. The American College of Physicians, after examining 40 studies, concluded the decision to screen should be up to each man and his doctor. It’s a tough call because many tumors grow so slowly that men die of something else and because of the harm that can follow a suspicious screening test.

Younger men (between 50 and 69) may benefit more than older men because they have more years of life at stake. But even for them, screening yields on average only two extra weeks of life.

But the American Urological Association does recommend annual PSA and digital exams beginning at 50 for most men, and at 40 for African Americans and men with a family history of prostate cancer. The American Cancer Society recommends an annual digital exam and PSA test beginning at 50 for men with at least a 10-year life expectancy and for younger men at high risk. But the society is considering changes in this recommendation.

And a government-funded panel, the US Preventive Services Task Force, which painstakingly reviewed the data on dozens of screening tests about a year ago, gives a “D” to both these tests, meaning there is fair evidence to recommend against them.

Colorectal cancer. In general, the evidence for screening is good and growing. One test, which examines stool specimens for blood, seems to reduce the risk of death from colorectal cancer by a third, says Dr. David Atkins, senior health policy analyst at the Agency for Health Care Policy and Research.

Another, called flexible sigmoidoscopy, in which a doctor uses a viewing tube to examine the rectum and lower colon, reduces the death risk by 60 percent. Many doctors think it’s better to do both tests, though this is unproved.

And the consensus is in flux. Last week, the cancer society issued new guidelines, saying that at 50 everyone should have either a stool test plus a sigmoidoscopy, with repeat tests every year and five years respectively, or a total colon exam.

The total colon exams means either a colonoscopy – a viewing tube exam of the whole colon – or a barium enema, with these tests repeated every 10 years or 5 to 10 years, respectively.

Breast cancer. For women between 40 and 49, the whole issue of screening is a “mess,” says Dr. Jerome Kassirer, editor in chief of the New England Journal of Medicine.

In January, the NIH panel concluded it could not recommend regular mammograms for younger women. Last week, the American Cancer Society went the other way, strengthening its previous guidelines to recommend annual mammograms for women in their 40s. Yet another panel, the National Cancer Advisory Board to the National Cancer Institute, is still considering the issue.

The value of breast self-exams is debatable, too. The task force gives them a “C.” And a recent study of more than 267,000 Chinese women failed to find the exams reduced the death rate, though the women were followed for only five years.

Cervical cancer. Pap tests – at least every three years – rank among the best screening tools. Every year, Pap tests find serious, precancerous conditions in 300,000 women who need treatment. But the tests also pick up mild abnormalities in 2 to 3 million others, for whom the next step in not clear.

The National Cancer Institute is assessing the options: minor surgery, repeat Pap tests in six months or testing for human papillomavirus, which causes cervical cancer.

For any test, especially those about which experts disagree, the best course “is to engage your doctor in a discussion of the facts, particularly the facts of your own history,” says Dr. Larry Gottlieb, deputy medical director at Harvard Pilgrim Health Care.

This, unfortunately, is getting ever tougher, as managed care chips away at the amount of time doctors have to talk.

But it is “high time,” says Dr. David Rosenthal, president-elect of the American Cancer Society, “to rely less on blanket screening and put decision-making back where it belongs, into the hands of the doctor-patient team.”

Medical screening tests: Which are worth doing?

An analysis of the major screening tests by the US Preventive Services Task Force, a government-funded panel, found little scientific justification for routine use of many procedures.  The rankings apply to healthy, asymptomatic people at normal risk of disease. Tests were graded A to E.

A – Good evidence to recommend the test
B – Fair evidence to recommend the test
C – Insufficient evidence either way
D – Fair evidence against screening
E – Good evidence against *

 

The rush is now on to Echinacea

March 17, 1997 by Judy Foreman

The Cheyenne used it for sore gums, the Comanches, for toothaches and sore throats. Other Native Americans kept it on hand for snakebites or syphilis.

Modern Americans seem to love the stuff, too, even if we can’t pronounce it. In fact, echinacea – that’s eck-in-EH-shia – is now the top selling herbal remedy in health food stores, though garlic and ginseng claim top honors in overall sales.

Unlike many medicinal herbs, this daisy-like flower, also known as purple coneflower, quite literally has its roots in America, not Asia. And compared to many plant medicines, there’s a fair amount of research on it – 350 studies by some counts.

Some people swallow the nasty-tasting liquid form of echinacea or sip it as tea at the first sign of a cold or flu. Others use it as a salve on burns or wounds that won’t heal. Others gargle it for strep throats or take it, internally and externally, for herpes. Some even give it, in small doses, to their kids.

But at $ 10 to $ 20 a bottle for the liquid stuff – depending on how much you use, a bottle may last three weeks – should we?

The answer, say many pharmacognocists, or scholars of medicinal herbs, is a hearty “why not?” It appears safe for many people and may, as advertised, stimulate the immune system. If you’re allergic to ragweed, though, or have HIV/AIDS or an autoimmune disease like lupus or multiple sclerosis, you should probably give it a miss.

While some of the research on echinacea may still not meet rigorous scientific standards, researchers in Germany – where doctors prescribed echinacea 2.5 million times in 1994 alone – have come up with provocative findings in recent years.

In one double-blind, placebo-controlled study of 180 volunteers, a German team found in 1992 that high doses of an alcohol-based extract of Echinacea purpurea root seemed to reduce the severity and duration of cold and flu symptoms.

But the dose appeared to be crucial. People who took 900 milligrams (or 180 drops) a day showed significant improvement. Those who took half that were no better off than people given a placebo, or dummy drug.

In another 1992 double-blind, placebo-controlled study of 108 people with chronic upper respiratory infections, those given 4 milliters of E. purpurea in liquid form twice a day for eight weeks had fewer infections than those taking a placebo.

In 1994, another German researcher reviewed 26 controlled human studies. Together, he concluded, the studies suggest that echinacea can stimulate the immune system.

But caveats are in order. The studies involved three types of echinacea, as well as combinations of types, and the quality of some studies was low, warns Steven Foster, an Arkansas plant photographer who writes on herbal research for the American Botanical Council, a research and educational group.

While echinacea does not kill bacteria, research suggests it does increase the number of white blood cells, as well as the process of phagocytosis, or the gobbling up of invading organisms by immune cells. It may also block an enzyme that helps infections spread.

There’s some evidence that echinacea also stimulates cells called fibroblasts, which play a role in healing wounds, says Cathy Crandall, a researcher of medicinal plants at Washington University in St. Louis.

The problem, though, says Dr. Jerome Groopman, an immunologist and chief of experimental medicine at Beth Israel Deaconess Medical Center, is that “you’re kind of poking in a black box.”

Lots of natural products stimulate some parts of the immune system, he says, but what’s needed is a “rigorous evalution” of echinacea and other herbs.

Still, those who do study herbs seriously, among them Gail Mahady, a pharmacognocist at the University of Illinois in Chicago, say the data on echinacea are a lot more solid than that on some herbal remedies.

“I don’t think anyone could look through the literature and honestly say echinacea doesn’t stimulate the immune system,” she says.

Echinacea “is one of the few herbs I take,” adds Varro Tyler, who has studied dozens of herbs and is professor of pharmacognosy emeritus at Purdue University.

So far, no one is sure which of echinacea’s constituents might account for such effects, though there’s some evidence that one component, high molecular weight polysaccharides, can activate cells that gobble up invading germs.

A more pressing question, for most consumers, is which kind of echinacea – E. angustifolia, E. pallida or E. purpurea – to take, and in what formulation.

Most of the research has been done on E. purpurea, and it is this type of echinacea that the German Commission E, the leading authority on herbal remedies, recommends for colds and respiratory infections and for urinary tract infections as well.

The Germans endorse the above-ground parts of E. purpurea – not the roots – taken either as pressed juice in an alcohol solution or as an injection. (Injections of echinacea are not available in this country, though they are in Germany.)

There has been less study of E. angustifolia, notes Tyler, though he thinks the roots of this form may actually be the best product. In practice, many of the dozens of echinacea products sold in America are combinations of all three types.

If you do take a combination product, says Mahady of Chicago, try to get one that contains the above-ground parts of E. purpurea and the roots of E. angustifolia and E. pallida. Some products give this information on the label.

Mahady takes the stuff herself – the 22 percent liquid formulation, not the capsules – whenever she feels a cold coming on. “It tastes terrible,” she says, but seems to help.

And if you take echinacea, the German Commission suggests, stop before eight weeks because it loses effectiveness over time.

Dr. Carol Englender, a Newton physician who also uses herbal remedies, says she recommends echinacea often. “Just today, I told four people to take it for the rest of the winter,” she said recently. “It’s good stuff.”

And while some think echinacea in an alcohol solution works best, Englender believes the capsules are effective, too.

Dr. Edward Chapman, another Newton physician who recommends echinacea to patients, adds that “the nice thing is it’s safe, and you can use if for kids.”

For adults, he says, the usual recommendation is 90 drops a day – you quickly learn how to gauge how many drops are in a dropperful – spread over three doses. Manufacturers – backed by German research – often recommend as much as 150 drops a day. For small children, Chapman says, 10 drops a day often help, and for kids between 5 and 10 years of age, 20 drops.

But the bottom line, says Arkansas herbalist Foster, is that when it comes to choosing the best dose and a formulation, “what we don’t know is greater than what we do know.”

Fuzzy thinking about herbs

Despite the booming popularity of herbal remedies among consumers, a number of myths remain, perhaps the silliest of which is the idea that anything “natural” must be safe and anything synthetic, dangerous.

But mushy thinking among fans of herbal medicine often goes further than that, verging on what Varro Tyler, an herb scholar and professor of pharmacognosy emeritus at Purdue University, calls “paraherbalism,” a belief in the superiority of anything natural and organic.

Other tenets of paraherbalism, which Tyler discusses in his 1994 book, “Herbs of Choice,” include these beliefs:

  • There is a conspiracy by the medical establishment to discourage the use of herbs. Wrong, says Tyler. It’s just that doctors know little about herbs because medical schools don’t teach them and pharmaceutical firms don’t bother studying herbs because they see no profit in doing so.

  • Herbs cannot harm, only cure. Wrong again. Some highly toxic substances, including the amatoxins, strychnine, ricin and many others are derived from plants.

  • Whole herbs are more effective than their components. For every example that supports this, says Tyler, there’s another that contradicts it, because many herbs also contain toxins.

  • Reducing the dose of a medicine increases its efficacy.  This is a central tenet of homeopathy, an enterprise philosopically different from herbal medicine. Many scientists, Tyler among them, think homeopathy makes no sense.

  • Herbs were created by God specifically to cure disease. “This thesis,” as Tyler puts it, “is not testable and should not be used as a substitute for scientific evidence.”

Lymphedema finally getting some attention

March 10, 1997 by Judy Foreman

Marianne Lynnworth, 66, a writer and former geographer, isn’t sure why she got lymphedema, though she thinks a case of frostbite when she was a teenager probably touched off a hereditary tendency to the disease.

But she sure does know what a struggle it’s been for the last 52 years.

Sometimes, the swelling makes her legs so heavy it “zaps my energy,” says Lynnworth, who lives in Waltham. She can’t go shopping for more than an hour because standing in line becomes so difficult. “And I can’t wear dresses anymore because my legs look so swollen.”

For years, doctors had little to offer patients with lymphedema, a condition in which damage to the lymphatic system causes the arms or legs to swell to several times their normal size. It also sets the stage for massive infections from even the tiniest cuts in the skin.

In fact, lymphedema has until recently been such an orphan condition — it falls through the cracks of medical specialties — that even today no one is quite sure how many people have it.

Some put the figure at 1 to 2 million Americans, plus another 250 million worldwide, many in tropical countries where parasites cause a severe form of the disease called elephantiasis.

For some, lymphedema stems from genetic bad luck. Others acquire it after treatment for other diseases, usually cancer. Roughly half a million breast cancer survivors have it from surgery or radiation that destroys lymph nodes in the armpit; others get it in the legs after lymph nodes in the groin are destroyed by surgery or radiation for melanoma and prostate cancer.

But thanks to strenuous efforts by patient advocates and a growing understanding among doctors, lymphedema is finally moving out of the closet — and into the clinic.

In the last year and a half, five lymphedema programs have gotten going in the Boston area. Dozens more have sprouted nationwide, driven by the growing popularity of a low-tech treatment from Europe that, proponents say, combats many of the complications of lymphedema.

The lymphatic system, specialized vessels through which a clear, protein-rich fluid flows, is an under-recognized but crucial part of our circulatory and disease-fighting machinery.

It is “the garbage-hauling system of the body,” says Dr. Robert Lerner, a New York surgeon who has pioneered American lymphedema care and who, with Dr. A. Benedict Cosimi, now runs a new Boston clinic that opened in January, backed by Massachusetts General and Brigham and Women’s hospitals and the Dana Farber Cancer Institute.

In the bloodstream, much of what we call blood is actually plasma, a clear fluid. When you sprain your ankle, for instance, much of the swelling is plasma that seeps out of tiny capillaries into tissues around the injury. Most of this fluid is then reabsorbed into the bloodstream through small veins.

But a small part of it, called lymph, is picked up by lymphatic vessels instead, which carry it to a duct in the chest, from where it is dumped back into the primary circulation. The lymph often contains bacteria, dead white blood cells used to fight infection, proteins, fats, and, sometimes, cancer cells that have been shed from a tumor.

As lymph flows slowly back toward the primary circulation — there’s no pump like the heart to push it — the lymph nodes filter out the debris.

But if these nodes or lymphatic vessels are damaged, there is no place for the lymph to go, notes Dr. Sumner Slavin, a plastic surgeon and lymphedema researcher at the Beth Israel Deaconess Medical Center.

And as the fluid builds up, any cut in the skin can trigger a raging infection called cellulitis (not to be confused with the skin-puckering condition called cellulite). In fact, lymphedema provides a veritable feast for invading bacteria.

Each infection can lead to scar tissue that further damages lymph vessels, setting the stage for yet more lymphedema and cellulitis.

So the trick is getting the fluid that is stuck in a limb past the damaged lymph vessels and back into circulation.

Elevating the swollen arm or leg can help, but that’s often impractical on a sustained basis. Pneumatic pumps help, too, but they work best in the earliest stages of the disease. Once lymphedema has progressed to fibrosis, a hardening of the tissue, pumps may actually damage still-healthy lymph vessels.

Surgery to remove skin and fat and squeeze out fluid can help in extreme cases, but swelling almost always returns.

Diuretics — pills that reduce fluid retention — may get rid of excess lymph, but they leave behind a concentrated solution of lymph proteins that acts as a chemical magnet for more fluid. Another drug, coumarin, has been tried in some countries, though it’s not available not here. It has been linked to several deaths.

That leaves the low-tech stuff, typically a combination treatment called complete decongestive physiotherapy. This includes manually draining the lymph fluid, a technique in which a physical therapist lightly massages lymph vessels to stimulate lymph flow; scrupulous skin care to guard against infections; using non-elastic bandages that squeeze the limb tightly at the wrist or ankle, and exercises done while the bandages are in place.

Finding therapists trained to do lymph drainage can be tough.

The Spence Center for Women’s Health in Cambridge, believed to be the first local clinic to offer it, sent its lymph therapist, Cindy Stewart, to Canada for training.

At St. Elizabeth’s Medical Center, a lymphedema service, including a therapist, opened two weeks ago, says Dr. Kathleen Hogan, medical director for women’s health.

The Lahey-Hitchcock Medical Center in Burlington will open a lymphedema service as soon as its therapist finishes training, probably in May or June, says Dr. Donald Breslin, a peripheral vascular disease specialist. Mt. Auburn Hospital in Cambridge hopes to follow suit soon thereafter.

But promising as it sounds, hard data on the effectiveness of lymph drainage massage are scarce, says Slavin of Beth Israel.

Though apparently safe, the technique can be both “onerous and expensive,” he adds. Sessions cost roughly $100 each — insurance coverage is spotty at best — and many patients need one to two sessions a day for up to four weeks.

“That’s why I haven’t tried it,” says Allison Stieber, a 46-year-old Somerville copy editor who has had lymphedema for 17 years.

But Lerner says he has treated more than 4,000 people and has followed 2,000. Most of them, he says, experience a 60 percent reduction in swelling, progress that persists with an at-home maintenance program.

A study published in January in the journal Oncology suggests that in many patients, lymphedema can be reduced by at least two-thirds with the combined treatment.

Still, the ultimate solution may be a different approach to surgery — removing fewer lymph nodes in the first place — and perhaps new ways to get damaged lymphatic vessels to regrow.

Surgeons are already cutting back on the number of lymph glands they remove. At some hospitals, they are experimenting with removing only a few “sentinel” nodes in the armpits of women having breast surgery, says Lerner, especially if the women have small tumors and plan to have chemotherapy.

Most surgeons, though, are awaiting the results of a major study before changing their practice, says Dr. Susan Pories , a breast surgeon at Mt. Auburn and Beth Israel.

Slavin, meanwhile, is trying to coax damaged lymphatic vessels to regrow.

The bottom line, he says, is that “we should never underestimate the capacity of the human body to repair itself.”

Tips to prevent and help control lymphedema:

  • Keep the skin on the affected limb very clean.

  • Don’t cut your cuticles, because bacteria can enter the body through cracks in the skin. Use a cuticle cream instead.

  • Try to avoid having blood drawn from the affected arm.

  • Try to avoid having your blood pressure taken in that arm.

  • Seek treatment promptly for an injury or infection.

  • Avoid lifting heavy objects with the affected arm.

  • Wear gloves while gardening.

  • Wear a pressure sleeve during airplane travel.

  • Try to avoid scratches or bites from animals or insects; if they occur, seek treatment right away.

  • Avoid tight clothing.

  • Try to maintain optimum weight because obesity may make lymphedma worse.

  • Exercise may help.

  • Wear sunblock on the affected limb — it’s more susceptible to sunburn.

It’s enough to make you crazy

February 24, 1997 by Judy Foreman

Maybe your boss is driving you crazy. Or it’s dawning on you that your husband is acting just like your alcoholic father.

Maybe you can’t find a mate, or can’t commit when you do. Maybe you hear voices, or think about suicide. Or get so scared you can’t leave home. Or so depressed you can’t get out of bed.

Whatever the particular worry, you decide the time has come to embark on that quintessentially American solution to life’s woes: therapy.

The question is, what kind of therapy and with whom?

You’ve heard, of course, of psychoanalysis, and probably of psychodynamic therapy, too, where the idea is to understand your current troubles by tracing them to the emotional patterns laid down long ago in your family.

You may also have heard of cognitive behavioral therapy, through which you try to change unproductive thoughts and actions, regardless of who did what to whom 30 years ago.

And if you’re a denizen of New Age bookstores and the bulletin boards of the granola-and-tofu circuit, you’ve probably heard of the more far out stuff as well, like rebirthing, channeling, white goddess healing, aromatherapy or – the list is endless – even alien abduction therapy.

But with therapies mutating faster than the flu virus in a bad year and options ranging from the well-studied to the wacko, you could drive yourself nuts just trying to sort it all out.

But there are some useful guidelines to navigating the therapeutic seas, say both mainstream and not-so-mainstream shrinks. Berkeley psychologist Margaret Thaler Singer, for example, coauthored “Crazy Therapies,” a useful resource for anyone interested in the less traditional options.

Ultimately, of course, picking the right therapist can be as tricky, and personal, as choosing the right mate, but here are some tips that may help:

If you haven’t had a physical exam lately, get one. There may be an underlying physical problem.

Shop around, which means visiting at least two therapists.  You may be surprised how different it feels to talk to a man or a woman, to someone older or younger, to a doctor or a social worker, or someone of a different race or religion.

After each try-out visit, ask yourself how you felt. Did the therapist listen, or just try to sell you on his approach? Did she treat you with respect? Did you just plain like this person?

Be wary of any therapist who offers the first hour free. That may be a marketing gimmick, not a serious mental health consultation.

You may be attracted to both mainstream and alternative therapies, but mainstream shrinks, at least, overwhelmingly recommend seeing a licensed professional. This could be a psychiatrist (an M.D.), a psychologist, a social worker, or another professional, such as a psychiatric nurse, whose training and credentials meet a minimum standard required to be licensed by the state.

Obviously, a license is no guarantee of competence or compassion. But it’s better than no license, and it should mean the therapist has studied the basics, like how the mind works, different types of mental illness, family systems and the like.

Be skeptical, by the way, of anyone who does not have a license but hangs out a shingle as a “psychotherapist.” Legally, anyone from your car mechanic to your mother-in-law to a professional who been stripped of his license can call himself a psychotherapist.

Ask what training the therapist has had, and don’t be too easily dazzled. A few impressive-sounding weekend workshops are no substitute for years of graduate school.

Don’t pick a therapist from the phone book, a holistic health catalog, grocery store giveaways or any publication that’s mostly a marketing tool. Or if you do, at least ask for references from people who know this therapist’s work.

Be cautious about referrals from friends. A friend can be a great resource, especially if she’s no longer seeing the therapist she suggests. But in general it’s a bad idea to share therapists – you’re better off finding your own.

The best bet is to get referrals from a health professional, hospital or a mental health organization.

Steer clear of any therapist who offers simplistic, one-size-fits-all therapy that assumes everybody has the same problem. Ditto, if the explanation seems to lack common sense or be unrelated to the problem you went in with. If you have marital problems, for instance, it probably won’t help to be told you’ve been abducted by aliens or were someone else in a past life.

If you do have a specific problem, it may make sense to see someone with a defined specialty like, say, sexual abuse – though neither you nor the therapist should assume you fit this category without considerable discussion.

March right out the door if your therapist touches you – other than a hello and goodbye handshake – or comes on to you, sexually or emotionally. Some therapists feel an occasional hug is all right, but others strongly disagree.

Discuss fees upfront. Ask how many sessions insurance will cover (the state mandated minimum is $ 500). Ask if you will be billed for missed sessions. If you have managed care, ask if the therapist will fight for full coverage, which some insurers may make difficult. Avoid any therapist who offers to barter services, like giving you therapy for a picture you’ve painted.

Ask about your therapist’s orientation. Does he believe it’s important to understand the familial roots of your pain? Does he prefer to help you find ways to cope in the here and now? Think about how this approach fits with your own beliefs.

Ask what evidence there is that your therapist’s approach works, but bear in mind that many of the mainstream approaches have been found to be roughly equivalent.

A task force from the American Psychological Association recently ranked therapies according to evidence of efficacy. Some techniques clearly work, the group found, including cognitive therapy for anxiety and depression, therapy that examines interpersonal relationships in people who are depressed, and family therapy for schizophrenics and their relatives.

Other approaches probably work, among them behavior therapy for some types of drug abuse, some psychodynamic therapies and relaxation techniques for anxiety.

There’s less agreement on the efficacy of psychoanalysis, despite its longstanding reputation, or some newer controversial treatments like EMDR – eye movement desensitization and reprocessing, a technique that relies on eye movement exercises to relieve for post-traumatic stress disorder.

Be wary of any therapist who seems to be controlling you, including sequestering you from family and friends.

It’s one thing for a therapist to suggest that you not see your family right now because you are exploring possible abuse or that you steer clear of drinking buddies if you’re trying to get sober. It’s quite another to tell you to trust only him and prohibit any contact with people who are important to you.

Be open to group therapy. For some problems, this may be ideal, especially if you fear interacting with people, if you’re anxious, have an addiction or have the general sense that you don’t understand why people treat you the way they do. Self-help groups using the Alcoholics Anonymous model may also be useful.

Be wary of any therapy that leaves you feeling increasingly discouraged. It’s common to feel worse for a while when you get in touch with painful feelings, but it’s a red flag if you go endlessly downhill.

If you feel you are getting worse, discuss this with your therapist. If you are not satisfied with the explanation, get a second therapist to evaluate your progress.

Things get tricky at this point. You shouldn’t switch therapists to avoid your own deeper problems, but you should consider making a change if a therapist is not helping. This is particularly true if your therapist is not licensed or practices therapy for which there is little evidence, like “entities” therapy, in which you may be told that spirits from the dead are in your body.

If your emotional problems are severe, you might also consider prescription medications. For this you should consult a doctor, usually a psychiatrist, or a psychiatric nurse.

As you embark on therapy, give yourself credit for the courage it takes to confront your problems. And remember that many people feel they have benefited from therapy – of different kinds.

In a survey of 4,000 people by Consumer Reports in November 1995, for instance, people felt they made similar progress whether they saw a social worker, psychologist or psychiatrist. The survey also showed – the party line of the insurance industry notwithstanding – that the longer they stayed in therapy, the more progress they felt they made.

Remember that no matter which flavor therapy you choose, the key is often the relationship with the therapist.

So take your time and choose wisely.

  1. The sources for this story

The following people were interviewed for this column:

Anne Alonso, clinical professor of psychology, Harvard Medical School, past president of the American Group Psychotherapy Association.

David Barlow, professor of psychology and director of the Center for Anxiety and Related Disorders, Boston University.

James R. Council, psychologist, North Dakota State University, president of the psychological hypnosis division of the American Psychological Association.

Sharon Gordetsky, president-elect of the Masssachusetts Psychological Association.

Dr. Laura Kramer, a psychiatrist at Spectrum Medical Arts in Arlington, which combines Western and holistic treatments.

Robert P. Salvatore, a certified clinical social worker at LaMora Associates in Nashua, N.H., who specializes in EMDR (eye movement desensitization and reprocessing).

Margaret Thaler Singer and Janja Lalich, authors of “Crazy Therapies,” published by Jossey-Bass Publishers, San Francisco.

  1.  For help in finding therapist

For a referral to a mental health professional licensed in Massachusetts, try the following organizations. Your choices may be limited by your insurance coverage. If you are in the midst of a mental health crisis, go to the nearest hospital emergency room or call 911.

Massachusetts Psychological Association, 617-523-6320.

Massachusetts Psychiatric Society, 1-800-831-3134.

Massachusetts Nurses Association (for psychiatric clinical nurse specialists), 1-800-882-2056).

Massachusetts Chapter of the National Association of Social Workers referral service, 617-720-2828 or 1-800-242-9794.

Massachusetts Association for Marriage and Family Therapy, 508-345-3600.

Massachusetts School Psychologists Association, 617-422-1755.

Massachusetts Mental Health Counselors Association, 1-800-944-0934. For referrals in other states, try:

American Psychological Association, 202-336-5700.

American Psychiatric Association, 202-682-6220.

National Association of Social Workers referral line, 1-800-638-8799 ext. 291.

American Association of Marriage and Family Therapists, 202-452-0109.

To learn if a mental health professional is licensed or if there have been any complaints against him or her, call:

Office of Investigations of the Division of Registration, 617-727-7406; or

For psychiatrists, the Board of Registration in Medicine, 617-727-3086.

To get a background profile on a doctor, call 617-727-0773 or 1-800-377-0550.

 

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