Here’s the so-called problem: The kids in the Colorado Springs schools just aren’t drinking enough Coke, or so says John Bushey, an area superintendent for 13 schools who signs his correspondence, “The Coke Dude.”

It seems the Colorado district had been hard up for money for extras like band competitions and debates. So in 1997, it signed a 10-year contract by which it would get $8-$11 million from Coca-Cola in return for giving the soft drink giant exclusive rights to peddle Coke, juices, teas, other sugary drinks and fancy water in school vending machines.

Coke has similar “partnerships” with schools around the country, including the Burlington, Mass. system and dozens of individual schools in the Boston area, says Bob Lanz, Coke’s vice president for public affairs for New York and New England.

With sugar consumption by teenagers already in the stratosphere, this scheme is not exactly popular with nutritionists. Surprisingly, it doesn’t seem all that popular with kids in Colorado Springs, either, because they haven’t held up their end of this sugar-coated deal.

Sales of Coke products have been so sluggish that Bushey wrote to school officials in September: “We all need to work together to get next year’s volume up to 70,000 cases.”

He wasn’t kidding, as he made plain in an interview. In fact, his solution is to let kids buy drinks “throughout the day except for the half hour before and after lunch” and to place machines “where they are accessible all day.”

Let’s say, for argument’s sake, that bombarding kids with soda pop and other sugary drinks makes economic sense for cash-starved schools. But nutritional sense? Forget it.

Sugar consumption, especially among teens, is “off the charts,” says Michael F. Jacobson, executive director of the Center for Science in the Public Interest, a health advocacy group in Washington, D.C. The group lays much of the blame on the soft drinks, or “liquid candy,” that teens are guzzling.

(Sugar-free drinks aren’t much better, he adds. Artificial sweeteners “are used almost exclusively in worthless foods. If you’re consuming much of them, you ought to worry about your overall diet. They aren’t making good foods better, they’re making bad foods less bad.”

Twenty years ago, his group says, teens drank almost twice as much milk as soda. Now they drink twice as much soda as milk. Girls get only 60 percent of the calcium they need to build bones to prevent osteoporosis in later life. Some data suggest drinking soda instead of milk may also contribute to breaking bones while they’re still teenagers.

The US Department of Agriculture is worried, too, noting that Americans consume twice as much sugar as desirable. Indeed, many of us now get 16 percent of our calories from sugar, including table sugar and products like corn syrup that are added to processed foods.

It’s not that sugar is a toxin, as some health faddists argue. In and of itself, it’s not bad for you. It isn’t even a major risk for diabetes.

But too much sugar can make for health problems, including obesity, heart disease and tooth decay, said a panel of 21 nutritionists in December. They called for a National Academy of Sciences study of the health consequences of sugar consumption.

Metabolically, sugar is a refined carbohydrate, like white bread or potatoes. And, like them, it can trigger a rapid rise in blood glucose, which sets off an outpouring of insulin, the hormone that escorts sugar molecules into cells.

Over time, too much of this cycle can raise blood levels of fatty substances called triglycerides and lower levels of HDL (good cholesterol), increasing the risk of heart disease. There’s also some evidence that this carbohydrate-insulin cycle can exhaust the insulin-producing cells in the pancreas, says Dr. Walter Willett, chairman of nutrition at the Harvard School of Public Health.

But the main problem with sugar, aside from the calories it packs, is that “it squeezes out the good things” like fruits, vegetables and milk from the diet, says Dr. George Blackburn, medical director of the Center for the Study of Nutrition and Medicine at Beth Israel Deaconess Medical Center. Sugar is just “empty calories,” agrees Willett, adding that an eight-ounce serving of Coke contains about eight teaspoons of sugar.

“If people thought of spooning down eight teaspoons of sugar, they’d be grossed out,” he says. “But drinking makes it virtually invisible, which means you can take in a lot more calories than you realize.”

And too many calories, regardless of where you get them, leads to weight gain, unless you exercise off what you take in.

Sugar is also seductive. “It’s not only in things that are sweet, which we know have sugar, but it’s also in processed foods that don’t taste particularly sweet,” says Larry Lindner, executive editor of the Tufts University Health & Nutrition Letter. That includes ketchup, canned beans, barbeque sauce, spaghetti sauce, even cereals that don’t appear to be sweet.

But to focus solely on sugar – and not on refined carbohydrates in general – is to miss the point, nutritionists say, because in some ways, pure sugar may be less of a problem.

“People have been given the idea they can load up on potatoes and bagels but not sugar,” says Willett. In fact, table sugar (sucrose) is made up of both fructose and glucose. Because fructose does not trigger an insulin response like glucose, in some ways, ironically, you may be better off eating pure sugar than starch, in terms of metabolic effects on the body, he says.

“No matter how you take carbohydrates in, enzymes in the pancreas turn it all to sugar,” adds Blackburn. “What the body sees is sugar. It never sees a starch.”

What, then, is a body to do?

Remember the basics – calories do count, and sugar, especially in liquid candy form, can be an insidious wrecker of healthy diets. Weight control, no matter what the fad diet books say, still boils down to a matter of “calories in, calories out,” says Karen Chalmers, director of nutrition services at the Joslin Diabetes Center in Boston.

The bottom line is that you should eat a diet that’s roughly half carbohydrate, including sugar. Within that category, you should try to eat less of the refined stuff, which has had much of the fiber and many of the nutrients removed, and more of the whole grain products like brown rice or whole oats.

And soft drinks? Forget it. If you’re thirsty, drink water. (Juices are okay in small quantities, but they have lots of calories.) If you’re hungry, eat real food.

1: Substitutes can be risky

If you spend time on line, chances are you’ve stumbled upon e-scares about artificial sweeteners, especially aspartame, or NutraSweet, which is alleged to cause methanol toxicity, headaches, brain cancer, lupus, and multiple sclerosis.

In truth, methanol toxicity (which can cause blindness) from aspartame is not a serious concern, says Timothy Maher, director of pharmaceutical sciences at the Massachusetts College of Pharmacy. In fact, there’s more methanol in a can of tomato juice than a soda sweetened with aspartame, which was approved by the US Food and Drug Administration for use in some food products in the early 1970s and for soft drinks in 1983.

“There is some evidence that aspartame may be linked to migraine headaches,” he says, but there’s no credible evidence of any link between aspartame and brain tumors, MS, or lupus, although that’s largely because these haven’t been studied.

There is a danger that anti-aspartame crusaders often don’t talk about, however, the fact that some people can’t metabolize one of the two amino acids (phenylalanine) in aspartame.

Those are people born with a condition called PKU (phenylketonuria). Since children with PKU cannot metabolize phenylalanine, they must eat a special diet to avoid proteins that contain the amino acid, or they run the risk of becoming mentally retarded and dying young. If these children consumed aspartame, “it would really do them in,” adds Maher.

Thanks to genetic screening at birth, however, most people with PKU know it. But this test doesn’t pick up people – a few percent of the population – who inherit just one defective gene for PKU, not two. This means you could be at risk for an adverse reaction from aspartame and not know it.

In addition, some data suggests that schizophrenics who react adversely to antipsychotic drugs such as Haldol also may not be able to metabolize aspartame normally. If they consume it, their reaction to the medications, including involuntary muscle movements, may get worse, says Maher.

In other words, if you’re worried about aspartame, don’t touch it. There are other sweeteners on the market, including Acesulfame K and saccharine, though they’re controversial, too, according to the Center for Science in the Public Interest.

On the other hand, the health advocacy group says, the newest sweetener, Sucralose, approved by the FDA in July, does appear safe.

Even so, the take-home message, as Maher puts it, is “I’d use sugar.” In moderation, of course.

By the spoonful

There is plenty of sugar in many common processed foods. A single teaspoon of sugar weighs about five grams.

Sugar in grams

Sources of sugar Serving size	Grams
Pepsi 12 fl. oz.	41
Coke Classic 12 fl. oz.	39
Hershey’s milk chocolate bar 1.6 oz.	22
Kellogg’s Fruit Loops 1 cup	15
Nabisco Double Stuf Oreos 2 cookies	13
Dannon French Vanilla Lowfat Yogurt 1 cup with Raspberries	51
Dannon Premium Plain Lowfat Yogurt 1 cup	16
Ocean Spray Jellied Cranberry Sauce 1/4 cup	26
Mott’s Apple Sauce 1/2 cup	23
Mott’s Natural (unsweetened) Apple Sauce 1/2 cup	12
HI-C Orange Drink 8 fl. oz.	31
Tropicana Pure Premium Orange Juice 8 fl. oz.	22
Whole orange 5 oz.	12
General Mills Almond Oatmeal Crisp 1 cup	16
Kellogg’s Corn Flakes 1 cup	02
Prego Pasta Sauce (Traditional) 1/2 cup	15
Campbell’s Old Fashioned Beans 1/2 cup	14
Campbell’s Home Cookin’ Tomato Garden Soup 1cup	12

SOURCE: Tufts University Health and Nutrition Letter.

It sounds promising: You boot up your computer, go to one of the new prescription drug Web sites, type in your name, health insurer, credit card number and address, and ask your doctor to call or fax in your prescription.

Presto! Within a day or so, your medication arrives on your doorstep by mail, UPS or Fedex. No driving to the drugstore. No parking. No standing in line while harried druggists fill your order.

A month ago, the first major Internet pharmacy, Soma.com, went on line with a prescription service, which has already filled thousands of orders through a distribution center in Ohio. By the end of the first quarter, PlanetRx.com and Drugstore.com, with distribution centers in Tennessee and Texas respectively, promise to be up and running, too.

The American Association of Retired Persons (AARP), a longtime mail order prescription giant, recently added on-line ordering for its members, at www.rpspharmacy.com. So has Merck-Medco, which provides prescription drug benefits to health plans and employer groups, though it handles only refills, not new prescriptions, on line (www.merck-medco.com).

With prescription drug sales a booming $88-billion-a-year business, virtual pharmacies were probably inevitable. But it’s too soon to tell how well they’ll work and how different they’ll be from mail order services.

The hope is that Internet pharmacies will make drug shopping even easier than by mail order, says Andy Stergachis, director of pharmacy services at Drugstore.com. You’ll be able to order nonprescription items like vitamins and shampoo along with your antibiotics, for instance, and you can ask your virtual pharmacist questions as well. You will also get e-mail reminders when prescriptions need to be refilled, he says.

True, you have to send personal information into cyberspace, but there are at least some assurances of confidentiality. At PlanetRx.com, privacy will be assured with “the highest level” of encryption, says Stephanie Schear,a founder and vice president of business development.

And if all goes according to plan, on-line pharmacies will fill prescriptions as ethically as your local drug store.

At Soma.com, your doctor must call or fax in the prescription. The pharmacists are required to call the doctor to verify that he or she is legit and the prescription is correct. They’re also supposed to make sure your new drugs won’t conflict with what you’re already taking.

In theory, the virtual pharmacies will also be duly licensed in the states from which they distribute drugs and will be licensed or registered in every state where they have customers as well.

In reality, though, cyber pharmacies, which are expected to be fiercely competitive, are springing up in a regulatory limbo. Is there anyone minding the virtual store?

“There’s not, in my opinion,” says Dr. James Winn, executive vice president of the Federation of State Medical Boards.

The Federal Trade Commission is concerned mostly with deceptive practices, not violations of standards of care, he notes. The Food and Drug Administration’s job is to oversee drug quality, not the practice of medicine by doctors and pharmacists, who, like pharmacies, are licensed state by state.

And therein lies the rub.

In some states, including Massachusetts, the state has no jurisdiction over out-of-state pharmacies, including the mail order firms that have been around a while, because it has no law requiring they be registered, says Chuck Young, director of the state’s Board of Registration in Pharmacy. If there were such a law, the state could initiate legal action if a Massachusetts resident were harmed by prescription drugs shipped from out of state.

“This whole issue is just exploding right now,” says Young. “We’re doing the best we can. But electronic changes are occurring at a faster rate than regulatory boards can keep up, given the resources they’re provided. I would want to be convinced these drugs are being packaged in conformity with federal and state law.”

Another problem is that it may be difficult for consumers to distinguish between on-line pharmacies that are legitimate and those that aren’t, says Carmen Catizone, executive director of the National Association of Boards of Pharmacy.

Some Web sites have already been criticized for having doctors write prescriptions, most notably for the potency pill Viagra, for patients they have never even seen, a medical practice widely viewed as unethical.

“We’re trying to come up with some system for consumers to differentiate between legitimate on-line pharmacies and the not-so-legitimate,” Catizone adds. “In the meantime, consumers should not order any medications over the Internet from sites that don’t assure you that your doctor has been contacted.” (You can also check with your doctor.)

It also may be risky to get some prescription drugs on the Web and others at your local drugstore. “So if you’re switching to an on-line pharmacy, that pharmacy needs to know what else” you’re taking because of potential drug interactions, says Susan Winckler, director of policy and legislation for the American Pharmaceutical Association.

To guard against this danger, new customers at Drugstore.com must fill out a form indicating what other medications they’re taking and what allergies and medical conditions they have. All prescriptions are checked against this information.

Another issue is how Internet pharmacies will deal with controlled substances, says Dr. Helga Rippen, director of the Health Information Technology Institute at Mitretek Systems, Inc., a nonprofit technology think tank in McLean, Va.

Drugstore.com won’t fill prescriptions for narcotics such as Percodan and Demerol, though this type of prescription can be filled at neighborhood drugstores, says pharmacist Stergachis. Drugstore.com will fill prescriptions for some painkillers and sleeping pills, however, after checking with your doctor.

In general, Stergachis says, the on-line service plans to call the patient’s physician “if there is any reason to suspect any type of a problem or if clarification is needed,” just as pharmacists are supposed to do already in local drugstores. (With the on-line service, just as in the current system, there’s no automatic way to tell if this consultation does occur.)

Despite such concerns, ordering prescription drugs on line may not turn out to be all that revolutionary. After all, says Schear, PlanetRx’s founder, “We’re not changing anything about the existing system. You go to a doctor. You say you want your prescription filled from PlanetRx. They fax or call us just as they do today.”

“We plan to verify prescriptions,” she adds, precisely how she won’t say, for competitive reasons, until the site is launched.

Stergachis agrees that in many ways, on-line pharmacy services will be “similar to mail order services,” which account for about 13 percent of the prescription drug business.

In fact, if there’s a downside to all this, that may be it.

Even with the net, there will “still have to be contact between the pharmacist and the physician,” says Ed Spearbeck, senior vice president of corporate and pharmacy affairs for the AARP. “That is time-consuming. I’m not sure people are prepared to understand that fully.”

Using an on-line pharmacy

 – Check to see whether the on-line service is willing to contact your doctor to verify prescriptions, especially for controlled substances such as painkillers and sleeping pills.

• If you have any doubts about whether your personal medical information will be kept confidential, don’t use that site.
• Call the board that licenses pharmacies in your state and ask if they have received any complaints about the site you want to use; also ask whether your state has a law giving it jurisdiction over out-of-state pharmacies.
• If there’s anything that doesn’t look right when you get the medication, don’t take it. If your current medication is green and you get red pills, for instance, don’t take them.
• If the package looks like it’s been opened or tampered with, don’t take the medication.
• If you order some medications on line and others from your regular pharmacy, tell both pharmacists what other medications, vitamins, herbal supplements and the like you are taking, to minimize the danger of adverse interactions.

You’ve had a cold for days now. You’re sneezing. Your throat hurts. Your nose is stuffy. You’re coughing. And you’re just plain sick of being sick. Is it time to see a doctor?

Or, your kid has been in earache hell all winter. She’s just finished a course of antibiotics, but she still has fluid behind her eardrum. Should she take even more antibiotics?

Or, your face hurts. Your sinuses ache. Even your upper teeth are in agony. Yellow-green gunk is pouring out of your nose. Is this just a bad cold or something worse? Do you need antibiotics?

It’s that awful time of year, when colds, flu, allergies, sinusitis, and ear infections not only plague but perplex. How do you know which misery you’ve got? How do you know which symptoms to tolerate and which to treat? Most urgently, how do you know when you really need antibiotics?

It is a crucial question. Antibiotics are life-saving in some situations, but ineffective in others – worse than ineffective, because the more widely antibiotics are used, the more bacteria around the world become resistant to them, ultimately rendering the drugs useless.

Cancer drugs, by contrast, affect only the person who takes them. But an antibiotic affects not just your health but potentially that of everyone in the world, notes Dr. Stuart B. Levy of the Tufts University School of Medicine, who heads the Center for Adaptation Genetics and Drug Resistance.

When you take an antibiotic, it kills off some of the hundreds of strains of bacteria in your body, wiping out those that are sensitive to it but leaving those that are not, says Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases in Bethesda, Md.

“The few resistant ones that are already there will then repopulate, so you have replaced sensitive ones with resistant ones,” Fauci says. That means you now harbor more dangerous bacteria that could make you sick in the future, and next time, when you need antibiotics, the drugs may not work. It also means you can now spread more resistant bacteria to other people.

In addition to the possibility of being infected by resistant strains from someone else, you develop your own. Bacteria are always dividing, and as they do, they sometimes mutate. Some mutants by chance will be resistant.

Already, several deadly strains of bacteria are so resistant they evade every antibiotic available – more than 100 drugs, says Levy of Tufts medical school. And while some of this problem may be due to widespread use of antibiotics in cattle feed, much of it is because people take antibiotics when they don’t need to. The Centers for Disease Control and Prevention estimates that 50 million of the 150 million outpatient antibiotic prescriptions a year are unnecessary.

So, when do you really need them?:

• Sore throat. The only time antibiotics are appropriate is for strep throat, caused by the Streptococcus bacterium, says Dr. Richard Besser, a pediatrician and epidemiologist at the CDC. To know whether you have strep, you need a throat culture, which can take several days, or a five-minute “rapid test,” though some insurers won’t pay for the latter. But most sore throats are viral, not bacterial, and antibiotics do not work against viruses. If you have a runny nose and cough along with your sore throat, chances are you have a virus, not strep.
• Sinus infections and colds. Every year, Americans suffer a billion colds; kids average six to 10 a year, adults two to four, government figures show. Since colds are caused by viruses (more than 200 different ones, in fact), antibiotics won’t help. But colds can lead to secondary bacterial infections in the sinuses.

There’s no easy test to tell a cold from sinusitis, but there are clues.

Colds usually last less than 10 days; sinus infections, more than 10. With a cold, the nasal discharge is thick and whitish or thin and watery; with a sinus infection, the discharge is likely to be thick and yellow-green and you may have a fever. (The CDC, however, notes that sometimes even yellow-green mucus can be caused by a viral, not bacterial, infection.)

Other signs of sinus infection include a feeling of facial pressure, fatigue, and tooth pain, says Dr. Marvin Fried, chief of otolaryngology at Beth Israel Deaconess Medical Center and Brigham and Women’s Hospital.

If you do have a sinus infection, it’s probably bacterial, and you need antibiotics, says Dr. Ralph Metson, an ear, nose, and throat surgeon at the Massachusetts Eye and Ear Infirmary. And if you have repeated bouts that don’t respond to antibiotics – more than three a year – you may need surgery to enlarge sinuses that have become blocked by allergies, colds, or polyps.

• Coughs. In children, most coughs, and even bronchitis (inflammation of the bronchial tubes), are viral and don’t warrant antibiotics, says Besser of the CDC. In adults, especially smokers, bronchitis may be bacterial and need antibiotics. At any age, if your cough is prolonged or you’re very sick, you should see a doctor because you may have pneumonia. Since pneumonia is often caused by bacteria, antibiotics are warranted.
• Earaches. More antibiotics are prescribed for kids’ ear infections than for anything else, the American Academy of Pediatrics says, and many are unneeded. In fact, about 50 percent of the bacteria that most commonly cause ear infections are now believed to be resistant to antibiotics.

The problem is that there are two types of earaches, and only one warrants antibiotics. That one is acute otitis media, which causes pain, fever, inflammation, and pus that’s often visible behind the eardrum.

The other, otitis media with effusion, often follows the acute form, even after antibiotics, and can last for months. While there’s also fluid behind the eardrum in this condition, the fluid is clear and there’s usually no pain. Antibiotics aren’t usually needed.

In fact, if doctors differentiated between these two types of earaches and held back more often on antibiotics for otitis media with effusion, 8 million unnecessary courses of antibiotics could be avoided every year. But day-care centers often won’t re-admit kids who’ve been sick unless they kids are on antibiotics. One solution to that, the CDC says, is for doctors to write a note to the child’s day-care center explaining why antibiotics are not needed.

• Flu (influenza). People often confuse colds and flu, but the symptoms are different. With flu, there’s usually a fever, a prominent headache, and exhaustion. If you’re not sure what you have, see your doctor, and ask to be tested. There are now more than a half-dozen rapid diagnostic tests for flu, according to the US Food and Drug Administration. If you do have the flu, two drugs, amantadine and rimantadine, can reduce symptoms.

Regardless of which form of respiratory misery you’ve got, remember that “the body’s immune system cures most infections, whether they’re caused by bacteria or viruses. Otherwise, the human species would not have survived, even before the advent of antibiotics,” says Metson of Mass. Eye and Ear.

“Nevertheless, if you think your infection is severe, see your doctor. Antibiotics can relieve symptoms and can be lifesaving.”

As bacteria fight back, world health woes are feared

In the 1940s, when antibiotics were developed, they were seen, rightly, as miracle drugs. Indeed, the ability to save lives by killing deadly bacteria is a milestone of modern medicine.

But now, 50 years later, these drugs have been used so often – and often, so unnecessarily – that bacteria are becoming resistant, creating a potentially disastrous health problem.

Already, the death rates from some diseases, such as tuberculosis, are rising again after having decreased for decades, says Dr. Stuart B. Levy at Tufts University School of Medicine.

Bacteria can become resistant to antibiotics in several ways. They can spontaneously undergo mutations that allow them to evade antibiotics. They can also acquire “resistance genes” by swapping DNA with other bacteria.

And in any given body or community, strains of bacteria that are resistant can become dominant if antibiotics kill off other bacteria with which they compete.

Researchers have found, for instance, that when one member of a household chronically takes an antibiotic for acne, other members develop skin bacteria resistant to that antibiotic.

More alarmingly, in many parts of the world, strains of the deadly Staphylococcus aureus are now resistant to all antibiotics except the potent vancomycin. And many strains of “staph,” a major cause of hospital-acquired infections, are becoming resistant to vancomycin as well, says Levy.

This means that strains of bacteria “untreatable by every known antibiotic are on their way,” he adds.

Worldwide, part of the problem is that farmers use antibiotics to boost growth in animals, Levy adds. Long-term exposure to low doses of antibiotics means animals may harbor resistant bacteria that can be passed to people. So far, the World Health Organization says, there is “little documented impact of this resistance on human health,” but the potential for harm is there and more data are needed.

You can help yourself – and the rest of society – by not pressuring doctors for antibiotics for viral infections. The drugs won’t work against viruses.

You should also take all the pills in any course of antibiotics you’ve been prescribed, for several reasons. If you don’t, you may leave alive bacteria that are less susceptible and most likely to become resistant. These bacteria may also make you relapse . And you might be tempted to use leftover antibiotics for some disease for which they’re not appropriate.

You should also avoid antibacterial soaps, hand lotions, and disinfectants, says Levy. There’s no evidence they ward off infection and they may contribute to antibiotic resistance.

Doctors and nurses can help by washing their hands – with regular soap – after every patient they see. Many don’t. And they should resist patient pressure for antibiotics if they’re unneeded.

For more information, you might want to read:

• “The Antibiotic Paradox: How Miracle Drugs Are Destroying the Miracle,” by Dr. Stuart B. Levy, Plenum Publishers, 1992.
• “Drug Resistance: The New Apocalypse,” special issue of Trends in Microbiology, Vol.2, No. 10, October 1, 1994.
• “Antibiotic Resistance: Origins, Evolution, Selection and Spread,” edited by D. J. Chadwick and J. Goode, John Wiley & Sons, 1997.
• “The Challenge of Antibiotic Resistance,” by Dr. Stuart B. Levy, Scientific American, March, 1998.
• On the Web, you can also check out www.antibiotic.org, the site for the Alliance for the Prudent Use of Antibiotics.

As a child, Louise Kennedy stuttered so badly that eventually she just stopped talking.

Now a 37-year-old administrator at Harvard’s John F. Kennedy School of Government, Kennedy recalls that the other kids in Dundee, Scotland, where she grew up, were merciless. One rode by on his bike yelling, “Stutterer, stutterer.” Others “tied me up and put me in a rubbish bin.”

Her father was even worse. “He refused to believe there was something wrong,” even as she dropped more and more words from her vocabulary, including, not surprisingly, “Daddy.”

“I’d say D-d-d-d,” she remembers. “He’d say, ‘Spit it out, girl.’ “

She just plain couldn’t.

Stuttering is a defect in which the flow of speech is broken up abnormally. Sometimes there’s no sound at all. Sometimes the stutterer repeats the beginning of a word, like st-st-stuttering. Sometimes there’s a prolongation of sounds, like ssssssstuttering. Sometimes the stutterer tries so hard to get words out he clenches his fist or starts developing facial tics.

For the 3 million Americans who stutter – and sometimes for those who listen – stuttering can be torture, partly because of sheer frustration but also because many people assume that someone who stutters must be dumb or emotionally disturbed.

Wrong. Scientists still don’t know exactly what causes stuttering, but they’re convinced it’s not nervousness or emotional problems, though stuttering can lead to both. But while the root causes remain elusive, researchers have developed increasingly refined therapies and uncovered important clues to the underlying biology of stuttering. For instance:

• Stuttering runs in families. If you have a parent, sibling or child who stutters, you are 5 to 20 times more likely to stutter than someone who has no such history – a clear sign that genes play a role, says geneticist Dennis Drayna of the National Institutes of Health.
• If one identical twin stutters, there’s a 25 to 80 percent chance the other will, too – another sign that genes are involved.
• If a child with biological parents who speak normally is adopted by a parent who stutters, there is no increased risk the child will stutter, according to a study of Colorado adoption records. This shows stuttering is not learned behavior, says the author, Susan Felsenfeld, a communication disorders specialist at Duquesne University.
• Brain imaging studies suggest the brains of people who stutter are different from those of people who don’t, says Dr. Anne Foundas, a behavioral neurologist at Tulane University School of Medicine.

In fact, Broca’s area – crucial for producing speech – is in the left hemisphere in most people. But stutterers often use the right hemisphere to produce speech, says speech-language pathologist Barry Guitar at the University of Vermont.

One reason stutterers may have trouble is that the right hemisphere processes nerve signals more slowly than the left. Since speech is being generated in the “wrong” place, the pathways that nerve signals must travel to produce it – from the brain to muscles in the mouth, tongue, lips and larynx – may be more convoluted than normal. Stuttering then could be the result of a timing or coordination glitch in these signals.

Even stutterers don’t always stutter. If they whisper or speak very slowly, for instance, some may speak fine. They may also be fluent if they wear earphones that delay the sound of their own speech, a device that can actually disrupt the speech of people who don’t stutter, says psychologist Ron Webster, director of the Hollins Communications Research Institute in Roanoke, Va. This suggests that feedback – hearing your own speech – is a key part of speech production.

Perhaps most intriguing, males stutter at four times the rate of females. Researchers don’t know why that is either, but stuttering usually starts in childhood, and some think female brains may be better able to rewire bad connections.

Recently, scientists have been trying a number of drug treatments for stuttering, including medications normally used for Parkinson’s disease or psychosis, on the theory that stutterers may have an abnormality in certain brain chemicals. Others have tried injecting botulism toxin into the vocal folds to stop muscle spasms that can disrupt speech.

So far, none of these approaches is a “magic cure,” says Charles Diggs, a speech-language pathologist at the American Speech-Language-Hearing Association in Rockville, Md.

What can work are techniques called fluency shaping and stuttering modification, which are sometimes taught together.

Fluency training, like that taught at Hollins, involves having the stutterer slow his speech down to the glacial speed of two seconds per syllable. Therapists then painstakingly teach the stutterer how to form each of the 35 sounds in English correctly, and how to coordinate breathing and speaking better.

After 19 intense days – and $3,200 – many people he has treated, including Louise Kennedy and Annie Glenn, the astronaut’s wife, emerge speaking far more fluently, says psychologist Webster.

The other approach involves teaching stutterers not to feel so anxious about stuttering and to “shape the stutter” so that they are in control of it, and not vice versa. This involves slowing down the part of the word that’s problematic and not struggling with the sound.

Jane Fraser, president of the Stuttering Foundation of America, says this worked for her father, who started the group in 1947. He taught himself to say his last name slowly, FFFFuuuhhhraser, to get the initial sound out.

What doesn’t work, say speech pathologists like Laura Barrett at the Franciscan Children’s Hospital and Rehabilitation Center in Brighton, is to substitute easy words for tough ones. The list of taboo words just grows.

It also helps to remember that many stutterers triumph over the disorder, including Winston Churchill, who become a great orator. But for many stutterers, just being able to speak normally is reward enough.

Not long ago, Louise Kennedy invited her boyfriend to have lunch with her father, who was visiting from Asia. Kennedy’s boyfriend raved about the progress she’d made, adding that he knew she’d had a bad problem when she was a child.

“Oh, it was just all in her mind,” Kennedy recalls her father saying, adding that she thinks now he was “afraid of not being able to fix it.” And that’s true, he couldn’t.

But she did. “I found my voice,” at Hollins. “The world is now my oyster.”

When you talk to a stutterer

• Be calm and patient. Maintain eye contact and pay attention to what the person is saying, not how he’s saying it.
• Don’t interrupt or finish the person’s sentence.
• Some speech fluency problems are normal in children, especially in chilren under 4. In older children or any child with severe or persistent problems, consult a speech-language pathologist.
• To help a child who stutters, provide opportunities for him to talk to you without distraction or competition from others.
• Don’t ask a child a lot of questions at once. Give your child time to answer one question before you ask another.
• Don’t tell the child – or any stutterer – to relax or slow down. This won’t help and calls attention to the stuttering.
• Be extra patient if you are talking to a stutterer on the telephone – this is a high stress situation.
• Remember that the stutterer is not doing this on purpose. Be kind – that’s what you’d want if you were the stutterer.

For more information, you may contact:

• The American Speech-Language-Hearing Association, 1-800-638-8255 or on line at www.asha.org. The group offers referrals to speech therapists anywhere in the country.
• The Stuttering Foundation of America can provide information and referrals, 1-800-992-9392 or on line at www.stuttersfa.org.
• The National Stuttering Project runs self-help groups nationwide, 1-800-364-1677 or on line at www.nspstutter.org.

Adolescence is hard enough, but when it comes to health care, teenagers are caught in a particularly delicate bind.

They’re old enough to face the same serious issues as adults — contraception, abortion, depression, alcohol or drug use — yet not old enough to have the same guarantees of confidentiality when they seek help.

Granted, confidentiality is not absolute for adults, either. If an adult poses a danger to himself or someone else, or is abusing or neglecting a child or a vulnerable adult, the doctor can, and often legally must, intervene.

But because adults can authorize their own care, and because they pay for it or have insurance that does, they have substantially more rights to confidentiality, at least in theory. Not so with teens.

In Wisconsin, teens can’t get any medical care care — except for evaluation of drug overdoses or in life-threatening emergencies — without prior written consent from a parent or guardian.

In most other states, a parent or guardian must authorize non-emergency care (not necessarily in writing), though teens can often be tested without parents knowing, and sometimes treated, for sexually transmitted diseases, including HIV infection, and for pregnancy diagnosis and contraception.

The degree of confidentiality a teenager has also depends on whether he or she is legally “emancipated” or “mature,” notes Richard Bourne, associate general counsel for Children’s Hospital in Boston.

In Massachusetts, for instance, a judge can decide that a teenaged girl is mature enough to make her own decision about abortion. In some cases, a doctor or other health care provider, rather than a judge, can decide that a teenager, male or female, is mature enough to consent to certain types of care.

But for many teenagers caught between childhood and adulthood, confidentiality can be elusive.

Teens often “go to a doctor for advice because they don’t want to ask their parents about something or don’t want to alarm their parents,” says Jeff Maranian, 17, an Arlington High School senior and member of an ongoing teen council convened by Tufts Health Plan to enlighten doctors on how teens want to be treated.

“Confidentiality is extremely important to teenagers,” he adds. He has no problem with doctors’ telling parents a teen is suicidal. But drug use?”No, that could be worked out between the doctor and patient.”Contraception? “I don’t think a parent needs to know about that.”

Indeed, with some issues like HIV, it may be “safer for the teen if the parent doesn’t know about the testing itself,” says Nicole Dray, a 16-year-old Lexington High School student who is also on the Tufts council.

“If they feel their parent will flip out about their having the test, they might not have it, which would be bad,” she says. “Some parents might think that if a teenager wanted the test, it means they are having sex with lots of partners or are using drugs. It might just mean they had sex once and want to be sure they’re okay.

“On the other hand, if they have the test and it’s positive, they obviously will have to tell their parents at some point.”

Several studies back up the notion that teens are more likely to confide in doctors if they know their concerns will be kept confidential, says Dr. S.Jean Emans, chief of the division of adolescent and young adult medicine at Children’s Hospital.

Ideally, pediatricians should raise the issue of confidentiality when the child is 10 or 11, says Dr. Michael McKenzie, assistant medical director for pediatrics at Tufts Health Plan.

“I do it in front of the parents. I say, `When you begin to see me by yourself — and that decision is up to the teen — that what we talk about is confidential.” He adds that if the teen threatens harm to himself or others, “that may be cause to talk to your parents against your wishes.”

And he forewarns: “If I hear something from you that I think your parents need to know and help you with, I will find a way to broker this, to help you talk to your parents about this.”

But it gets sticky, especially in “family practice,” where everybody in the family has the same doctor. Privacy can also get compromised in schools, where parents may have a right to see school records, including those of a school counselor. And there’s even less confidentiality for teens who are delinquent, in jail or on court probation.

Basically, medical and psychiatric care for adolescents boils down to a matter of “conditional confidentiality,” says Emans.

Part of the problem is that kids are caught in an “economic trap,” says clinical psychologist Gary Schoener, who specializes in ethical and legal issues and runs the Walk-In Counseling Center in Minneapolis.

Like battered women whose husbands pay the bills, teens may see their confidentiality shattered because parents either pay for their care or see insurance records.

What may work best is for the doctor to figure out, with the teenager, how to tell parents what’s going on or persuade parents to back off enough to give the teenager some privacy.

Sometimes, it helps to bring parents into the office, instead of just coaching the teen on how to talk to parents. Sometimes, it means persuading a teen to let parents know some things but not everything.

And in some cases, teens find it helpful to turn to the Internet with questions they might be afraid to ask a doctor in person, says Dr. Steven Adleman, medical director of substance abuse services at Harvard Vanguard Medical Associates in Boston. He runs a website, www.drsteve.org, which, he says, is increasingly being used by teens with questions about their use of alcohol, drugs and tobacco.

“I feel safer asking someone who can’t see me,” wrote one high school senior concerned about binge drinking. Another teen, an eighteen-year-old high school dropout who uses drugs, wrote, “This site is great for someone like me who is afraid to go to the doctor and afraid that my parents will find out I use drugs.”

But even with the best intentions, confidentiality can be jeopardized in situations that no one could have foreseen, says Thomas Grisso, a clinical psychologist and director of forensic training and research at the University of Massachusetts Medical School.

That can happen, for instance, when a teenager has been in psychotherapy for a while. Then the parents divorce, and a custody battle ensues. Sometimes, the court appoints a guardian to protect the teen’s interests. But the attorney for one side may subpoena the teenager’s therapist.

“Now you have the clinician stuck between his ethical obligation to maintain confidentiality to the child. . .and the legal order,” says Grisso.

The bottom line is not that you shouldn’t seek mental health or medical care when you need it. You should. But do so with your eyes open.

“Be neither blindly trusting nor blindly cynical,” advises Dr. Harold Bursztajn, who co-directs the program in psychiatry and the law at the Massachusetts Mental Health Center, a Harvard teaching hospital.

“If the doctor raises the question about getting in touch with your parents, go ahead and think of why or why not and talk about it,” he says. And if the answer is no, “say what you are afraid of, because there is something there that needs to be addressed, and it may not be in your mind.”

SIDEBAR

 How emancipation works

Teenagers may think that nothing sounds better than being emancipated from their parents but, legally, “emancipation” is a complicated and not always desirable state.

In general, however, teenagers have more rights to confidentiality if they are deemed “emancipated” or “mature,” though the definitions of these terms vary from state to state.

In Massachusetts, for instance, a teenager seeking an abortion has to get permission from a parent or guardian, or from a judge (which is called “judicial bypass”). In some states, parents must be notified, but getting their permission is not necessary. 

Once a judge deems a teenage girl to be a “mature minor,” she can make up her own mind about abortion. And sometimes, it doesn’t take a judge’s ruling to deem a teen mature — a doctor or other health care provider can make that decision

Emancipation also gets tricky.

By Massachusetts law, for instance, someone under 18 is emancipated if he or she is married, widowed or divorced; is a member of the armed forces; has a child; or lives independently from parents and is managing his or her own financial affairs (even if, as some interpret it, this means living on the streets and panhandling.)

If you’re an emancipated teenager, you can authorize your own care and therefore are entitled to more confidentiality.

In some states, including Massachusetts, you can also be emancipated under particular conditions, such as pregnancy or having a disease, including a sexually transmitted disease, that poses a risk to public health.

You can also be emancipated if you are 12 or older and are drug-dependent. The idea is to allow the teen to be assessed or treated without parents knowing, though doctors must tell parents if the condition poses a danger to life or limb.

You feel sluggish, dizzy, distracted. In fact, you’ve been at work all morning and haven’t gotten a thing done. You e-mail your doctor, describing your misery in excruciating detail.

Your employer, quite legally, reads it, and concludes you’re not really sick, just goofing off. Now you’re in deep yogurt.

Or, you run out of Prozac. You e-mail your shrink, who calls in a prescription. You’re fine – until your employer gets sued for something unrelated and all company e-mail within certain dates, including yours, winds up in court.

Or how about this scenario? You seek a second opinion on line from a doctor you’ve never met. You explain the diagnosis from the first doctor. The on-line doctor recommends a different treatment. You do it. It makes you worse. You sue. You lose; turns out there was no real doctor-patient relationship.

In its own way, the Internet may be changing the practice of medicine as much as antibiotics, anesthesia or immunizations.

The wealth of health information – and misinformation – on line is unimaginably vast. There are 40 million Americans on line and 15,000 to 25,000 web sites for health matters, says Dr. Helga E. Rippen, a physician-engineer who runs a health information institute at Mitretek Systems, a nonprofit technology think tank in McLean, Va.

Nearly 40 percent of Americans with on-line access use the web to search for health information, a survey by Princeton Survey Research Associates and the Institute for the Future, a California think tank found.

Through the web, people find new medicines, needle-in-a-haystack experts and support. But they are also finding, or soon will, that cyber medicine has pitfalls as well as promise.

Like e-mail.

“This is a technology that, like it or not, we are all going to be using,” says Dr. Daniel Z. Sands of Beth Israel Deaconess Medical Center, a co-author of new guidelines on doctor-patient e-mail put out by the American Medical Informatics Association (www.amia.org).

Both patients and doctors tend to be naive about the dangers of medical e-mail. It’s inappropriate in emergencies, for instance – you should call your doctor or 911. In fact, it often takes 48 hours for a busy doctor to answer e-mail.

Confidentiality is another huge risk. E-mailing your doctor from work is dicey because your employer may see it. At home, especially if you share a computer with your spouse or kids, e-mail from your doctor may wind up on a screen everybody can see. In the doctor’s office, a nurse or others may be deputized to read e-mail – and put a copy in your patient record.

In between, in the vastness of cyberspace, your e-mail is vulnerable to busybodies hacking their way. So it’s wise to encrypt medical e-mail, which you can do through a number of “applications” (software) says Alissa Spielberg, a medical ethicist at Harvard Medical School.

Be careful if you fill out any medical forms on line, or otherwise divulge personal medical information, too. Make sure there’s a lock icon in the lower left corner, which means whoever has designed the form has included encryption, says Rippen.

Even with these precautions, be careful about discussing sensitive information such as psychiatric problems, HIV status, abortion decisions or disability claims on interactive web sites or by e-mail.

That said, doctor-patient e-mail is expected to grow because patients like the fact that e-mail helps them get through to doctors, bypassing secretaries, nurses, switchboards, and busy signals.

Doctors appear more reluctant. So far, only 1 to 2 percent use e-mail to communicate with patients, estimates Dr. Tom Ferguson, a health informatics professor at the University of Texas and editor of the Ferguson Report, an industry newsletter about on-line health information.

In part, this is because doctors fear that answering patients’ e-mail will take them time and pay nothing.

That’s true, but even so, it may be worth it, some say.

In a study published in October in the Journal of the American Medical Association, Dr. Stephen M. Borowitz, a pediatric gastroenterologist at the University of Virginia Health Sciences Center in Charlottesville, analyzed more than 1,200 e-mails from worried parents over a three-year period.

He found that it takes only four minutes, on average, to read and respond to an e-mail and that most can be answered within 48 hours. Parents also seem to feel freer on e-mail to ask questions they fear are “too basic or too stupid” to ask in person, he adds. To help with just such basics, he’s developed a number of online “tutorials” to which he directs parents with sick kids.

To help doctors cope with the inevitable growth of patient e-mail, Dr. David Stern, an internist at the Ann Arbor Veterans Affairs Medical Center and the University of Michigan Health System, is studying more than 50 young doctors.

Half of them will communicate with patients only in traditional ways, and half will add e-mail to their interactions, and he’ll compare the outcomes. The results aren’t in yet, he says, but he hopes to find out whether e-mail helps or hurts overall communication with patients and whether it saves or costs time.

And what about getting medical advice from on-line docs?

So far, there are about 10 on-line medical consult services. But while there are benefits to such cyber consults – such as getting detailed opinions about a proposed treatment plan – there are also questions:

Can you get personalized care from a doctor you’ve never met? How do you know your consultant is really a doctor? Does an on-line consult constitute a doctor-patient relationship? Can doctors, licensed state by state, practice on line across state lines? Do cyber doctors increase their risk of malpractice?

“People should be very cautious,” says Bill Silberg, new-media editor at JAMA. Even if you hook up with top authorities, it’s not clear the advice would be as tailored to you as what you’d get from your own physician. “That personal connection in extremely important, but this is an evolving field,” Silberg adds.

“I’d be quite wary,” adds Spielberg of Harvard. Despite doctors’ disclaimers, she notes, “Once money is exchanged, you’d have a good argument that a doctor-patient relationship exists. If harm occurs, you may have a claim for malpractice.”

Dr. James Winn, executive vice president of the Texas-based Federation of State Medical Boards, agrees, adding that his group has written model legislation – adopted by a dozen states – stipulating that when the patient and doctor are in different states, the patient’s jurisdiction should prevail.

The group also recommends that states issue a limited license to doctors from other states who offer electronic consultations.

Massachusetts has not adopted the model law, but is working on the issue, says Alexander Fleming, executive director of the state board of registration in medicine.

At Mediconsult.com, which offers consults from doctors in various states through a service called MediXperts, medical director Michel Bazinet and his staff say they have taken great pains to tiptoe through this legal minefield.

They say their services – $195 per consult – do not constitute a doctor-patient relationship or second opinion because the doctor never knows the patient’s name, only the case number. The patient also pays the service, not the doctor. The company insists that it does “not practice medicine with this service.”

Maybe. But the bottom line is that cyber medicine – whether e-mail, health-oriented web sites or on-line consults – is such an exploding field that lawyers, legislators and ethicists, let alone average patients, aren’t keeping up.

Which means: Think before you type.

Cyber tips for patients and doctors

For patients:

1. Don’t use e-mail for emergencies or other situations in which you need a timely response. Call your doctor or 911.
2. Don’t assume e-mail is confidential. Don’t discuss psychiatric problems, HIV status, abortion, disability claims or other sensitive issues by e-mail.
3. Double-check the e-mail address you’re sending to.
4. Identify yourself by name in the subject line. Don’t expect the doctor to decipher a cutesy e-mail address.
5. Assume that whatever you write to your own doctor will end up in your medical record. Keep copies of all medical e-mail.
6. If you e-mail your doctor from your workplace, know that your employer is legally entitled to read it.
7. If you e-mail your doctor from home and you share your computer with family members, be aware that your e-mail may be read by others.
8. Encrypt your medical e-mail.
9. If you fill out forms on line with personal medical information, make sure the web site encrypts this information.
10. Ask if the doctor will send your e-mails to insurers.
11. Getting second opinions or other medical consults on line may be helpful, but use caution about taking medical advice from a doctor you have never met.

Parker Beck, now 5, seemed normal when he was born, say his parents, Victoria and Gary Beck of New Hampshire, who run an educational-products business out of their home. He grew, learned a few words, did all the usual “toddler things.”

Then, at 15 months, he suddenly stopped speaking. He developed chronic diarrhea. Most bizarrely, he began spinning in circles.

He had brain scans, allergy assessments, blood work. The Becks suspected autism, a disorder once deemed rare but now known to be common, affecting 1 to 2 in every 1,000 people.

But first they needed to rule out a digestive disorder, because of the diarrhea. So Parker had an endoscopy, a test for which he was given Secretin, a drug approved to help diagnose pancreatic cancer.

Afterward, he began speaking again and had “incredible leaps of development,” says his mom, whose scientific sleuthing — all done on her own — rivals that in the film, “Lorenzo”s Oil,” the 1992 film in which parents search for a treatment for a son with a rare genetic disease.

Was it the Secretin that helped Parker Beck? The Becks began begging researchers to find out. They spread the word to other parents, read medical books, and even wrote a book.

Soon, the Internet crackled with questions from parents, like Eileen and Sean Martin of Salisbury, who are 31 and spend five hours a day on line seeking help for their two autistic children.

Recently, after a story about Secretin aired on national TV, the Becks got 800 calls in two days and thousands of letters.

“I can’t answer them,” Victoria says. “I’m a regular mom with two kids.”

But she’s also at the center of a maelstrom in the desperate world of autism.

Years ago, autism — a developmental disorder characterized by language problems, social withdrawal, learning disabilities and repetitive behavior — was presumed to be caused by bad mothering.

Now, researchers think the disorder — which affects 400,000 Americans, four times as many males as females — may be linked to a complex array of problems, including defects in anywhere from two to seven genes, environmental factors like viruses, exposure to chemicals or vaccines, an autoimmune abnormality or some combination of these.

Some children develop a type of autism if they get an extra piece of chromosome 15 from their mothers, but not an extra piece from their fathers, says Dr. Edwin Cook, director of developmental neuroscience at the University of Chicago.

Autistic children are not retarded; in fact, autism can strike people of normal or high intelligence, says Marie Bristol-Power, a specialist at the National Institute of Child Health and Human Development in Bethesda, Md.

It affects several areas of the brain, including the cerebellum, which helps maintain attention; the amygdala, which is important for memory and emotions; and the hippocampus, a crucial component in memory.

Though some children aren’t diagnosed until age three — and some, like Parker Beck, develop language and other skills only to lose them — autopsy studies suggest the initial damage may occur before birth, before the 30th week of pregnancy, possibly preventing key brain areas from maturing normally.

Even babies who appear normal at birth may not be, say researchers who’ve looked at videotapes of first-birthday parties of kids later diagnosed with autism and found subtle clues that others missed — poor eye contact, or a child not reaching to be picked up or not recognizing a family member.

Those who think a virus is the cause note that years ago, before vaccines dramatically reduced the incidence of rubella (German measles), autism rates were high among children born to women who had rubella during pregnancy.

But some people blame the vaccines themselves. Parker Beck’s cognitive skills regressed soon after his immunization at 15 months against measles, mumps and rubella, his mother says.

So far, there’s “no strong scientific evidence that would cause you to say there’s a link” between autism and vaccines, “but there are enough scientific questions remaining that you also cannot say there is none,” says Kathleen Stratton, a pharmacologist at the Institute of Medicine in Washington who has held workshops on the issue.

There is no cure for autism. But 30 years of research supports the efficacy of applied behavioral analysis, a painstaking method by which a tutor teaches a child one skill at a time. To learn how to wash his hands, for instance, a child is taught to pick up the soap, turn on the water, rub his hands together, one step at a time, a process that can take weeks.

And drugs, especially antidepressants known as SSRIs or selective serotonin re-uptake inhibitors, can also help, especially in children and adults who are anxious and frustrated.

And earlier this year, researchers showed an anti-psychotic drug called Risperidone reduced aggressiveness in autistic adults. Trials are now under way to see if it works in children, too.

Some researchers think vitamin B6 supplements may also help.

But the big buzz is over Secretin, a hormone made by Ferring Pharmaceuticals in Tarrytown, N.Y. Because it is FDA-approved — as a single dose to help diagnose pancreatic problems — it is not illegal for doctors to prescribe it “off-label” for other purposes. And many do, with desperate parents and willing doctors often hooking up through the Internet.

By Victoria Beck’s estimate, 1,000 autistic kids have been given Secretin, many more than once.

In fact, there’s been such a run on the drug that the manufacturer says it will be in “short supply” into 1999. (The Becks are seeking a “new use” patent for Secretin and plan to donate proceeds to research.)

The child health institute has received so many questions it has posted a statement on the web (www.nih.gov/nichd) — saying it has no position on Secretin because there’s so little data.

In fact, the only published research was a report in January by the University of Maryland researchers who treated Parker Beck. They found that Secretin did appear linked to a “dramatic improvement” in behavior, eye contact, language, and alertness in Parker and in two other children.

That’s not exactly overwhelming evidence, and even Victoria Beck guesses that Secretin may help less than 50 percent of the time.

There’s no obvious reason why a drug that boosts pancreatic juices might combat autism, although the “gut-brain” theory of autism suggests a link between cognitive and digestive problems. Nor is it clear whether Secretin has bad side effects, though none have surfaced so far.

So it’s no wonder that some families, like the Martins of Salisbury, remain “wary” about giving Secretin to their autistic children. And others, like Joan Fallon, a 39-year-old Marshfield woman who has 36-year-old twin brothers with autism, worry about Secretin”s safety and efficacy in autistic adults.

The answers will only come with clinical research, and several researchers, including psychiatrist Cook of Chicago, are about to begin careful placebo-controlled, double-blind studies.

“I understand the desperation fueled by this disorder, . . . and that desperation should fuel our devotion to developing cures that are proven,” says Cook, who had an autistic brother and has spent his career trying to understand the disease. But until those data are in, “it is cruel to wave the flag of cure before there’s more certainty.”

True, but that could be months or years. In the meantime, the families of autistic patients can at least raise the issue with doctors — and learn all they can from those who’ve tried it.

• National Alliance for Autism Research, 1-888-777-6227 (On the web, www.naar.org)
• Autism Society of America, 1-800-328-8476 (On the web, www.autism-society.org/
• Cure Autism Now, 1-213-549 0500. (CAN has started a gene bank for families with more than one member affected by autism. If you want to participate, call this number.) On the web, www.canfoundation.org.
• Autism Research Institute, 1-619-281-7165, which has compiled information on Secretin.
• The Giving Back Fund, which manages the Doug Flutie, Jr. Foundation for Autism, 1-617-556-2820. (This fund, established by the Buffalo Bills and former Boston College quarterback whose son is afflicted, helps low income families of children with autism.)
• Language and Cognitive Development Center in Boston, a school for children with autism, 1-617-522-5434 or 1-800-218 5232. (web site: www.millermethod.org)
• National Institute of Child Health and Human Development, 1-800-370-2943
• National Autism Hotline, 1-304-525-8014.
• National Organization for Rare Disorders, 1-800-999-6673. (web site, www.rarediseases.org)
• The Option Institute, 1-800-714-2779 or on the web, www.option.org

“Unlocking the Potential of Secretin,” a book by Gary and Victoria Beck, is available for $15 through the Autism Research Institute. Proceeds go to the institute. Send check to: Autism Research Institute, 4182 Adams Ave., San Diego, CA 92116, or fax credit card order to: 619-563-6840.