Do cold medications cause prostate problems?

No. But pseudoephedrine, which is ubiquitous in decongestant cold remedies, may bring undetected prostate problems to light. Usually, these problems – chiefly trouble with urination due to an enlarged prostate – go away when the medication is stopped. Virtually all men develop an enlarged prostate as they age, which makes them have to urinate more frequently but is not an indication of cancer.